H-89

BrC1=CC=C(\C=C\CNCCNS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C=C1

InChIKey=ZKZXNDJNWUTGDK-NSCUHMNNSA-N

InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
cAMP-dependent protein kinase (PKA) 18 Target ID: CHEMBL2094138 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12963496	Inhibitor 8297	135.0 nM [Ki]
Ribosomal protein S6 kinase beta-1 1 Target ID: P23443 Gene ID: 6198.0 Gene Symbol: RPS6KB1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17214602	Inhibitor 8297	80.0 nM [IC50]
Ribosomal protein S6 kinase alpha-5 1 Target ID: O75582 Gene ID: 9252.0 Gene Symbol: RPS6KA5 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17214602	Inhibitor 8297	120.0 nM [IC50]
Rho-associated protein kinase 2 25 Target ID: O75116 Gene ID: 9475.0 Gene Symbol: ROCK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17214602	Inhibitor 8297	270.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:22:15 GMT 2023` Edited by `admin` on `Fri Dec 15 19:22:15 GMT 2023`
Record UNII	M876330O56
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

H-89

Common Name

English

5-ISOQUINOLINESULFONAMIDE, N-(2-((3-(4-BROMOPHENYL)-2-PROPEN-1-YL)AMINO)ETHYL)-

Systematic Name

English

N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

449241