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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO4
Molecular Weight 315.3636
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TALIBEGRON

SMILES

O[C@@H](CNCCOC1=CC=C(CC(O)=O)C=C1)C2=CC=CC=C2

InChI

InChIKey=SRBPKVWITYPHQR-KRWDZBQOSA-N
InChI=1S/C18H21NO4/c20-17(15-4-2-1-3-5-15)13-19-10-11-23-16-8-6-14(7-9-16)12-18(21)22/h1-9,17,19-20H,10-13H2,(H,21,22)/t17-/m0/s1

HIDE SMILES / InChI

Molecular Formula C18H21NO4
Molecular Weight 315.3636
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Talibegron (ZD2079) is a β3 adrenoceptor agonist and insulin sensitiser. It was developed as a potential treatment for obesity and non-insulin-dependent diabetes mellitus. Talibegron hydrochloride had been in phase II clinical trials by AstraZeneca for the treatment of type 2 diabetes and obesity. However, this research has been discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

Rats: Male and female rats were dosed separately by gavage for a minimum of 28 days with 0, 10, 30, and 150 mg/kg/day of Talibegron (ZD2079).
Route of Administration: Oral
Talibegron (ZD2079) produced a concentration-dependent (10(-6)M - 10(-3)M) relaxation of the rat isolated carotid artery rings preconstricted with U-46619.
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:53:01 GMT 2023
Edited
by admin
on Sat Dec 16 17:53:01 GMT 2023
Record UNII
M7O3VK2O7W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TALIBEGRON
INN  
INN  
Official Name English
talibegron [INN]
Common Name English
BENZENEACETIC ACID, 4-(2-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)ETHOXY)-
Common Name English
(4-(2-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)ETHOXY)PHENYL)ACETIC ACID
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C48149
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
Code System Code Type Description
SMS_ID
300000028993
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
PRIMARY
PUBCHEM
158794
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
PRIMARY
ChEMBL
CHEMBL1616411
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
PRIMARY
NCI_THESAURUS
C90793
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
PRIMARY
FDA UNII
M7O3VK2O7W
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
PRIMARY
INN
8137
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
PRIMARY
CAS
146376-58-1
Created by admin on Sat Dec 16 17:53:01 GMT 2023 , Edited by admin on Sat Dec 16 17:53:01 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY