PRENALTEROL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H19NO3
Molecular Weight	225.2842
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PRENALTEROL

SMILES

CC(C)NC[C@H](O)COC1=CC=C(O)C=C1

InChI

InChIKey=ADUKCCWBEDSMEB-NSHDSACASA-N

InChI=1S/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3/t11-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C12H19NO3
Molecular Weight	225.2842
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-1 adrenergic receptor 158	Partial Agonist 290		280.0 nM [Ki]

PubMed

Show entries

Title	Date	PubMed
Noninvasive assessment of chronotropic and inotropic response to preferential beta-1 and beta-2 adrenoceptor stimulation.	1984 Jun	6145533
Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.	1989 Mar	2564629
beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation.	1999 Sep	10465291
Ion-selective electrode for the determination of prenalterol.	2003 May 1	18969017
Towards a thermodynamic definition of efficacy in partial agonism: The thermodynamics of efficacy and ligand proton transfer in a G protein-coupled receptor of the rhodopsin class.	2010 Nov 15	20727346

Showing 1 to 5 of 5 entries

Patents

Sample Use Guides

In Vivo Use Guide

The eight patients were given prenalterol (PNL) orally, 30 to 200 mg/day, versus placebo for 6 days

Route of Administration: Oral

Substance Class	Chemical
Record UNII	M4G34404CX
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

PRENALTEROL

Official Name

English

prenalterol [INN]

Common Name

English

Prenalterol [WHO-DD]

Common Name

English

(-)-(S)-1-(P-HYDROXYPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL

Common Name

English

PRENALTEROL [MI]

Common Name

English

Showing 1 to 5 of 6 entries

Previous1 2Next

Show entries

Classification Tree

Code System

Code

Adrenergic and dopaminergic agents

WHO-VATC

QC01CA13

Adrenergic and dopaminergic agents

WHO-ATC

C01CA13

Showing 1 to 2 of 2 entries

Show entries

Code System

Code

Type

Description

INN

4121

PRIMARY

MESH

D011294

PRIMARY

FDA UNII

M4G34404CX

PRIMARY

SMS_ID

100000081428

PRIMARY

PUBCHEM

42396

PRIMARY

Showing 1 to 5 of 15 entries

Previous1 2 3Next

Show entries

Related Record

Type

Details


					U6VH18LCQ8

PRENALTEROL HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Showing 1 to 1 of 1 entries

Show entries

Related Record

Type

Details


					M4G34404CX

ACTIVE MOIETY

Showing 1 to 1 of 1 entries