PRENALTEROL HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H19NO3.ClH
Molecular Weight	261.745
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NC[C@H](O)COC1=CC=C(O)C=C1

InChI

InChIKey=WDXYIFGETVGLBZ-MERQFXBCSA-N

InChI=1S/C12H19NO3.ClH/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12;/h3-6,9,11,13-15H,7-8H2,1-2H3;1H/t11-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C12H19NO3
Molecular Weight	225.2842
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7270401 | https://www.ncbi.nlm.nih.gov/pubmed/3191661 | https://www.ncbi.nlm.nih.gov/pubmed/2572262

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-1 adrenergic receptor 158 Target ID: CHEMBL213 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1687080\|https://www.ncbi.nlm.nih.gov/pubmed/6131123\|https://www.ncbi.nlm.nih.gov/pubmed/6120845\|https://www.ncbi.nlm.nih.gov/pubmed/2564629	Partial Agonist 290		280.0 nM [Ki]

PubMed

Title	Date	PubMed
Noninvasive assessment of chronotropic and inotropic response to preferential beta-1 and beta-2 adrenoceptor stimulation.	1984 Jun	6145533
Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.	1989 Mar	2564629
Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.	1999 Nov	10531390
beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation.	1999 Sep	10465291
[Monoclonal gammopathy of undetermined significance (MGUS): establishment of premyeloma concept].	2002 Jul	12229119
Atypical cardiostimulant beta-adrenoceptor in the rat heart: stereoselective antagonism by bupranolol but lack of effect by some bupranolol analogues.	2003 Aug	12922943
Ion-selective electrode for the determination of prenalterol.	2003 May 1	18969017
Regulation of postburn ischemia by alpha- and beta-adrenoceptor subtypes.	2005 Mar	15683682
Positive inotropic and lusitropic effects mediated via the low-affinity state of beta1-adrenoceptors in pithed rats.	2005 Nov	16151438
beta(2) and beta(3)-adrenoceptor inhibition of alpha(1)-adrenoceptor-stimulated Ca(2+) elevation in human cultured prostatic stromal cells.	2007 Sep 10	17617401
Towards a thermodynamic definition of efficacy in partial agonism: The thermodynamics of efficacy and ligand proton transfer in a G protein-coupled receptor of the rhodopsin class.	2010 Nov 15	20727346

Patents

Sample Use Guides

In Vivo Use Guide

The eight patients were given prenalterol (PNL) orally, 30 to 200 mg/day, versus placebo for 6 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:44:11 GMT 2023` Edited by `admin` on `Sat Dec 16 05:44:11 GMT 2023`
Record UNII	U6VH18LCQ8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PRENALTEROL HYDROCHLORIDE

Official Name

English

CGP 7760B

Code

English

PRENALTEROL HYDROCHLORIDE [MI]

Common Name

English

PRENALTEROL HYDROCHLORIDE [USAN]

Common Name

English

H-133/22

Code

English

H 133/22

Code

English

PHENOL, 4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)-, HYDROCHLORIDE, (S)-

Common Name

English

PRENALTEROL HYDROCHLORIDE [MART.]

Common Name

English

(-)-(S)-1-(P-HYDROXYPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL HYDROCHLORIDE

Common Name

English

Prenalterol hydrochloride [WHO-DD]

Common Name

English

PRENALTEROL HCL

Common Name

English

CGP-7760B

Code

English

Code System Code Type Description

ChEMBL

CHEMBL1160714