PRENALTEROL HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H19NO3.ClH
Molecular Weight	261.745
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NC[C@H](O)COC1=CC=C(O)C=C1

InChI

InChIKey=WDXYIFGETVGLBZ-MERQFXBCSA-N

InChI=1S/C12H19NO3.ClH/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12;/h3-6,9,11,13-15H,7-8H2,1-2H3;1H/t11-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C12H19NO3
Molecular Weight	225.2842
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7270401 | https://www.ncbi.nlm.nih.gov/pubmed/3191661 | https://www.ncbi.nlm.nih.gov/pubmed/2572262

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-1 adrenergic receptor 158 Target ID: CHEMBL213 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1687080\|https://www.ncbi.nlm.nih.gov/pubmed/6131123\|https://www.ncbi.nlm.nih.gov/pubmed/6120845\|https://www.ncbi.nlm.nih.gov/pubmed/2564629	Partial Agonist 290		280.0 nM [Ki]

PubMed

Title	Date	PubMed
Noninvasive assessment of chronotropic and inotropic response to preferential beta-1 and beta-2 adrenoceptor stimulation.	1984 Jun	6145533
Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.	1989 Mar	2564629
Modulation of inotropic therapy by venodilation in acute heart failure: a randomised comparison of four inotropic agents, alone and combined with isosorbide dinitrate.	1992 Jan	1375684
beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation.	1999 Sep	10465291
Atypical cardiostimulant beta-adrenoceptor in the rat heart: stereoselective antagonism by bupranolol but lack of effect by some bupranolol analogues.	2003 Aug	12922943
Ion-selective electrode for the determination of prenalterol.	2003 May 1	18969017
alpha- and beta-adrenergic receptor mechanisms in spontaneous contractile activity of rat ileal longitudinal smooth muscle.	2005 Feb	15694819
Regulation of postburn ischemia by alpha- and beta-adrenoceptor subtypes.	2005 Mar	15683682
Recruitment of functionally active heart beta2-adrenoceptors in the initial phase of endotoxic shock in pithed rats.	2006 Nov	17047523
Role of selective alpha and beta adrenergic receptor mechanisms in rat jejunal longitudinal muscle contractility.	2008 Jun	17879122
Towards a thermodynamic definition of efficacy in partial agonism: The thermodynamics of efficacy and ligand proton transfer in a G protein-coupled receptor of the rhodopsin class.	2010 Nov 15	20727346

Patents

Sample Use Guides

In Vivo Use Guide

The eight patients were given prenalterol (PNL) orally, 30 to 200 mg/day, versus placebo for 6 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:44:11 GMT 2023` Edited by `admin` on `Sat Dec 16 05:44:11 GMT 2023`
Record UNII	U6VH18LCQ8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRENALTEROL HYDROCHLORIDE

Official Name

English

CGP 7760B

Code

English

PRENALTEROL HYDROCHLORIDE [MI]

Common Name

English

PRENALTEROL HYDROCHLORIDE [USAN]

Common Name

English

H-133/22

Code

English

H 133/22

Code

English

PHENOL, 4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)-, HYDROCHLORIDE, (S)-

Common Name

English

PRENALTEROL HYDROCHLORIDE [MART.]

Common Name

English

(-)-(S)-1-(P-HYDROXYPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL HYDROCHLORIDE

Common Name

English

Prenalterol hydrochloride [WHO-DD]

Common Name

English

PRENALTEROL HCL

Common Name

English

CGP-7760B

Code

English

Code System Code Type Description

ChEMBL

CHEMBL1160714