PITOFENONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25NO4
Molecular Weight	367.4382
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)C1=CC=CC=C1C(=O)C2=CC=C(OCCN3CCCCC3)C=C2

InChI

InChIKey=NZHMAQSCHUSSSJ-UHFFFAOYSA-N

InChI=1S/C22H25NO4/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23/h3-4,7-12H,2,5-6,13-16H2,1H3

HIDE SMILES / InChI

Molecular Formula	C22H25NO4
Molecular Weight	367.4382
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/international/pitofenone.html | https://www.ncbi.nlm.nih.gov/pubmed/15260106 | https://www.ncbi.nlm.nih.gov/pubmed/1777122 | https://www.medindia.net/doctors/drug_information/pitofenone.htm

Pitofenone is a spasmolytic agent. It exerts anticholinesterase and antimuscarinic activities. Pitofenone is used to relieve pain and spasms of smooth muscles. Pitofenone is also used for the treatment of back pain, sprains, and strains. Pitofenone is used in combination along with fenpiverinium bromide, and metamizole sodium. The drug is currently sold in Eastern Europe and India under various trade names. The combined preparation possesses strong analgesic, spasmolytic, cholinolytic and anti-inflammatory effects on the smooth muscles predominantly of the gastrointestinal and urogenital tract. Indications are strong pain in gastric or intestinal colic, kidney and gallstones, and for painful menstruation. Pitofenone hydrochloride present in the combination exerts papaverin-like spasmolytic effect on the vascular and extra-vascular smooth muscles of the stomach, intestines, urinary tract, biliary tract, and uterus.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Adrenergic receptor 35 Target ID: CHEMBL2331074 Sources: https://affygility.com/oel/pitofenone-hydrochloride.html \| https://www.ncbi.nlm.nih.gov/pubmed/6719639	Antagonist 2778
Acetylcholinesterase 207 Target ID: CHEMBL4768 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1777122	Inhibitor 8297	36.0 µM [Ki]
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: https://affygility.com/oel/pitofenone-hydrochloride.html \| https://www.ncbi.nlm.nih.gov/pubmed/6719639	Antagonist 2778

PubMed

Title	Date	PubMed
Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.	2004 Jun	15260106

Sample Use Guides

In Vivo Use Guide

The recommended dose of the pitofenone is 50 to 75 mg tablet. Pitofenone is part of an injection which contains 500 mg metamizole sodium, 0.02 mg fenpiverine bromide and 2 mg pitofenone hydrochloride in 1 ml of the solution.

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:49 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:49 GMT 2023`
Record UNII	M09N8K7YJY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PITOFENONE

Official Name

English

pitofenone [INN]

Common Name

English

Pitofenone [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698