PITOFENONE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25NO4.ClH
Molecular Weight	403.899
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC(=O)C1=CC=CC=C1C(=O)C2=CC=C(OCCN3CCCCC3)C=C2

InChI

InChIKey=ZRFIFDFEDPJBII-UHFFFAOYSA-N

InChI=1S/C22H25NO4.ClH/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23;/h3-4,7-12H,2,5-6,13-16H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	C22H25NO4
Molecular Weight	367.4382
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/international/pitofenone.html | https://www.ncbi.nlm.nih.gov/pubmed/15260106 | https://www.ncbi.nlm.nih.gov/pubmed/1777122 | https://www.medindia.net/doctors/drug_information/pitofenone.htm

Pitofenone is a spasmolytic agent. It exerts anticholinesterase and antimuscarinic activities. Pitofenone is used to relieve pain and spasms of smooth muscles. Pitofenone is also used for the treatment of back pain, sprains, and strains. Pitofenone is used in combination along with fenpiverinium bromide, and metamizole sodium. The drug is currently sold in Eastern Europe and India under various trade names. The combined preparation possesses strong analgesic, spasmolytic, cholinolytic and anti-inflammatory effects on the smooth muscles predominantly of the gastrointestinal and urogenital tract. Indications are strong pain in gastric or intestinal colic, kidney and gallstones, and for painful menstruation. Pitofenone hydrochloride present in the combination exerts papaverin-like spasmolytic effect on the vascular and extra-vascular smooth muscles of the stomach, intestines, urinary tract, biliary tract, and uterus.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Adrenergic receptor 35 Target ID: CHEMBL2331074 Sources: https://affygility.com/oel/pitofenone-hydrochloride.html \| https://www.ncbi.nlm.nih.gov/pubmed/6719639	Antagonist 2849
Acetylcholinesterase 209 Target ID: CHEMBL4768 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1777122	Inhibitor 8504	36.0 µM [Ki]
Muscarinic acetylcholine receptor 162 Target ID: CHEMBL2094109 Sources: https://affygility.com/oel/pitofenone-hydrochloride.html \| https://www.ncbi.nlm.nih.gov/pubmed/6719639	Antagonist 2849

PubMed

Title	Date	PubMed
Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.	2004-06	15260106

Sample Use Guides

In Vivo Use Guide

The recommended dose of the pitofenone is 50 to 75 mg tablet. Pitofenone is part of an injection which contains 500 mg metamizole sodium, 0.02 mg fenpiverine bromide and 2 mg pitofenone hydrochloride in 1 ml of the solution.

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:10:42 GMT 2025` Edited by `admin` on `Mon Mar 31 18:10:42 GMT 2025`
Record UNII	HE1ZA4ZBEX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BARALGIN

Preferred Name

English

PITOFENONE HYDROCHLORIDE

Common Name

English

METHYL 2-(4-(2-PIPERIDINOETHOXY)BENZOYL)BENZOATE HYDROCHLORIDE

Systematic Name

English

PITOFENONE HYDROCHLORIDE [MART.]

Common Name

English

PITOPHENONE HYDROCHLORIDE

Common Name

English

PITOFENONE HCL

Common Name

English

PITOPHENONE HCL

Common Name

English

Pitofenone hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

214-999-8