U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Cu.O4S.5H2O
Molecular Weight 249.685
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CUPRIC SULFATE

SMILES

O.O.O.O.O.[Cu++].[O-]S([O-])(=O)=O

InChI

InChIKey=JZCCFEFSEZPSOG-UHFFFAOYSA-L
InChI=1S/Cu.H2O4S.5H2O/c;1-5(2,3)4;;;;;/h;(H2,1,2,3,4);5*1H2/q+2;;;;;;/p-2

HIDE SMILES / InChI

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158https://www.ncbi.nlm.nih.gov/pubmed/16971307DOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217http://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttp://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/6526221http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356
Curator's Comment: description was created based on several sources, including https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1

Tetraamminecopper dihydroxide also known as Schweizer's Reagent dissolves cellulose; used in rayon production.

CNS Activity

Curator's Comment: Known to be CNS active in zebrafish. Human data not available.

Originator

Sources: http://pubs.acs.org/doi/abs/10.1021/ja01512a012Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Preventing
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
COPPER•MAX

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Preventing
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
Determination of protein by the biuret reaction using cupric hydroxide suspension reagent.
1960
Efficacy of burning, tillage, and biocides in controlling bacteria released at field sites and effects on indigenous bacteria and fungi.
1992 Apr
The effect of various fluoride compounds on the development of experimental root surface caries in hamsters.
1995 Dec
The genetics of tasting in mice. VII. Glycine revisited, and the chromosomal location of Sac and Soa.
1995 Oct
Copper Fluoride Luminescence during UV Photofragmentation of Bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)copper(II) in the Gas Phase.
1996 Aug 14
Cardiopulmonary events during hemodialysis: effects of dialysis membranes and dialysate buffers.
2000 Jul
The effectiveness of ecologically acceptable ways of protection of field-grown tomato (Lycopersicon lycopersicum (L.) Karsten) from tomato late blight (Phytophthora infestans (Mont.) de Bary) in extreme weather conditions.
2001
Direct catalytic aldol-type reactions using RCH2CN.
2003 Aug 21
Antioxidant activity of olive pulp and olive oil phenolic compounds of the arbequina cultivar.
2005 Mar 23
Cu(II) acetate- and Mn(III) acetate-mediated radical reactions of [60]fullerene with ketonic compounds.
2005 Mar 7
X-ray absorption spectroscopy study of a copper-containing material after thermal treatment.
2006 Apr 17
Acute copper toxicity following copper glycinate injection.
2006 Nov
A spectroscopic and thermoanalytical study of the mineral hoganite.
2007 May
Enhanced copper release from pipes by alternating stagnation and flow events.
2007 Nov 1
Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum.
2008 Jan
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.
2008 Nov 1
Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes.
2009 Jan 16
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate.
2009 Oct 30
Insight in the transport behavior of copper glycinate complexes through the porcine gastrointestinal membrane using an Ussing chamber assisted by mass spectrometry analysis.
2010 Apr
Copper-promoted coupling of vinyl boronates and alcohols: a mild synthesis of allyl vinyl ethers.
2010 Feb 3
Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles.
2010 May 19
Zinc prevents the copper-induced damage of cultured astrocytes.
2010 Oct
Anti-ovulatory activity of H2 receptor blockers in albino rabbits--a preliminary study.
2011 Apr
Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
2011 Dec 27
Rapid free chlorine decay in the presence of Cu(OH)2: chemistry and practical implications.
2011 Oct 15
Expeditious synthesis of phenanthrenes via CuBr2-catalyzed coupling of terminal alkynes and N-tosylhydrazones derived from o-formyl biphenyls.
2011 Oct 7
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3.
2012 Feb
CuBr2--a new multiferroic material with high critical temperature.
2012 May 8
Evaluation of topically applied copper(II) oxide nanoparticle cytotoxicity in human skin organ culture.
2013 Feb
Probing the chemical nature of dihydrogen complexation to transition metals, a gas phase case study: H2-CuF.
2013 Jan 18
Design, synthesis, antioxidant, and anti-breast cancer activities of novel diethyl(alkyl/aryl/heteroarylamino)(4-(pyridin-2-yl)phenyl)methylphosphonates.
2013 May
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses.
2013 Nov
Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties.
2013 Nov 25
The modality of cell-particle interactions drives the toxicity of nanosized CuO and TiO₂ in human alveolar epithelial cells.
2013 Oct 24
SILAC-based quantitative proteomic analysis of human lung cell response to copper oxide nanoparticles.
2014
Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.
2014
Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions.
2014
Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells.
2014 Jul
Electron induced surface reactions of organometallic metal(hfac)₂ precursors and deposit purification.
2014 Jun 11
CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin.
2015 Jun
A Facile Strategy for Catalyst Separation and Recycling Suitable for ATRP of Hydrophilic Monomers Using a Macroligand.
2016 Jan
Dissecting copper homeostasis in diabetes mellitus.
2017 Apr
Unusual 4-arsonoanilinium cationic species in the hydrochloride salt of (4-aminophenyl)arsonic acid and formed in the reaction of the acid with copper(II) sulfate, copper(II) chloride and cadmium chloride.
2017 Apr 1
Roles of Copper-Binding Proteins in Breast Cancer.
2017 Apr 20
Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities.
2017 Feb
Ultrasonic energy enhanced the efficiency of advance extraction methodology for enrichment of trace level of copper in serum samples of patients having neurological disorders.
2017 Jul
Amino acid-mediated 'turn-off/turn-on' nanozyme activity of gold nanoclusters for sensitive and selective detection of copper ions and histidine.
2017 Jun 15
Effects of Excess Copper Ions on Decidualization of Human Endometrial Stromal Cells.
2017 May
Patents

Sample Use Guides

In Vivo Use Guide
Copper 0.4 mg/mL (Cupric Chloride Injection) contains 0.4 mg copper/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving total parenteral nutrition, the suggested additive dosage is 0.5 to 1.5 mg copper/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg copper/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.
Route of Administration: Intravenous
Human Endometrial Stromal Cells were treated with non-toxic concentrations of copper ions (0-250 uM). mRNA expressions of insulin-like growth factor binding protein (IGFBP-1), prolactin (PRL), Mn-SOD, and FOXO1 were down-regulated during decidualization following the treatments with 100 or 250 uM copper ions. Meanwhile, the amount of malonaldehyde in the supernatant of cells was increased.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:28:12 UTC 2023
Edited
by admin
on Fri Dec 15 16:28:12 UTC 2023
Record UNII
LRX7AJ16DT
Record Status Validated (UNII)
Record Version
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Name Type Language
CUPRIC SULFATE
II   ORANGE BOOK   USP   VANDF  
Common Name English
CUPRIC SULPHATE PENTAHYDRATE
Common Name English
CUPRUM SULPHURICUM
HPUS  
Common Name English
SULFURIC ACID COPPER(2+) SALT (1:1), HYDRATE (1:5)
Systematic Name English
COPPER(II) SULPHATE PENTAHYDRATE
Systematic Name English
SULFURIC ACID COPPER(2+) SALT (1:1), PENTAHYDRATE
Common Name English
CUPRUM SULPHURICUM [HPUS]
Common Name English
CUPRIC SULFATE PENTAHYDRATE [MI]
Common Name English
COPPER(2+) SULPHATE (1:1) PENTAHYDRATE
Common Name English
Copper(2+) sulfate (1:1) pentahydrate
Common Name English
Copper sulfate pentahydrate [WHO-DD]
Common Name English
COPPER(2+) SULFATE PENTAHYDRATE
Systematic Name English
CUPRIC SULPHATE
Common Name English
CUPRIC SULFATE [VANDF]
Common Name English
COPPER(2+) SULPHATE PENTAHYDRATE
Systematic Name English
COPPER (AS CUPRIC SULFATE)
VANDF  
Common Name English
CUPRIC SULFATE [ORANGE BOOK]
Common Name English
COPPER SULPHATE PENTAHYDRATE
Systematic Name English
CUPRIC SULFATE [II]
Common Name English
COPPER SULFATE [VANDF]
Common Name English
CUPRIC SULFATE PENTAHYDRATE
MI  
Common Name English
COPPER SULFATE PENTAHYDRATE [EP MONOGRAPH]
Common Name English
COPPER (AS CUPRIC SULFATE) [VANDF]
Common Name English
COPPER SULFATE PENTAHYDRATE
EP   WHO-DD  
Systematic Name English
CUPRIC SULFATE [USP MONOGRAPH]
Common Name English
COPPER SULFATE [EP MONOGRAPH]
Common Name English
COPPER (II) SULFATE PENTAHYDRATE
Systematic Name English
COPPER(II) SULFATE PENTAHYDRATE
Systematic Name English
COPPER SULFATE
VANDF  
Systematic Name English
Classification Tree Code System Code
WHO-ATC V03AB20
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
WHO-VATC QV03AB20
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
CFR 21 CFR 184.1261
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
EPA PESTICIDE CODE 24401
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
FDA ORPHAN DRUG 586117
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
Code System Code Type Description
MERCK INDEX
m3913
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C65354
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
ChEMBL
CHEMBL604
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
CHEBI
31440
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
CONCEPT Industrial Aid
CAS
7758-99-8
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
ALANWOOD
copper sulfate
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
CAS
23254-43-5
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
NON-SPECIFIC STOICHIOMETRY
WIKIPEDIA
Cupric sulfate
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
SMS_ID
100000092181
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
RXCUI
21579
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY RxNorm
EVMPD
SUB11846MIG
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
CHEBI
23414
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
DAILYMED
LRX7AJ16DT
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
HSDB
2968
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
EPA CompTox
DTXSID9031066
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
MESH
D019327
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
DRUG CENTRAL
4282
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
EVMPD
SUB13460MIG
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
PUBCHEM
24463
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
DRUG BANK
DB06778
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
FDA UNII
LRX7AJ16DT
Created by admin on Fri Dec 15 16:28:12 UTC 2023 , Edited by admin on Fri Dec 15 16:28:12 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY