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Details

Stereochemistry ACHIRAL
Molecular Formula Cu.O4S.5H2O
Molecular Weight 249.685
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CUPRIC SULFATE

SMILES

O.O.O.O.O.[Cu++].[O-]S([O-])(=O)=O

InChI

InChIKey=JZCCFEFSEZPSOG-UHFFFAOYSA-L
InChI=1S/Cu.H2O4S.5H2O/c;1-5(2,3)4;;;;;/h;(H2,1,2,3,4);5*1H2/q+2;;;;;;/p-2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524https://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/16971307https://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlhttps://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/6526221http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfhttp://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356DOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725http://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026
Curator's Comment: description was created based on several sources, including https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1

Tetraamminecopper sulfate is a dark blue crystalline solid with a faint odor of ammonia. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Used as a pesticide and fungicide, to print fabrics (especially in calico finishing), and to make other copper compounds.

CNS Activity

Curator's Comment: Known to be CNS active in zebrafish. Human data not available.

Originator

Sources: http://pubs.acs.org/doi/abs/10.1021/ja01512a012Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Preventing
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
COPPER•MAX

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Preventing
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
A spectroscopic and thermoanalytical study of the mineral hoganite.
2007 May
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.
2008 Nov 1
Copper sulfide nanoparticles for photothermal ablation of tumor cells.
2010 Oct
Expeditious synthesis of phenanthrenes via CuBr2-catalyzed coupling of terminal alkynes and N-tosylhydrazones derived from o-formyl biphenyls.
2011 Oct 7
CuBr2--a new multiferroic material with high critical temperature.
2012 May 8
Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions.
2014
Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells.
2014 Jul
Electron induced surface reactions of organometallic metal(hfac)₂ precursors and deposit purification.
2014 Jun 11
A Facile Strategy for Catalyst Separation and Recycling Suitable for ATRP of Hydrophilic Monomers Using a Macroligand.
2016 Jan
Unusual 4-arsonoanilinium cationic species in the hydrochloride salt of (4-aminophenyl)arsonic acid and formed in the reaction of the acid with copper(II) sulfate, copper(II) chloride and cadmium chloride.
2017 Apr 1
Patents

Sample Use Guides

In Vivo Use Guide
Copper 0.4 mg/mL (Cupric Chloride Injection) contains 0.4 mg copper/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving total parenteral nutrition, the suggested additive dosage is 0.5 to 1.5 mg copper/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg copper/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.
Route of Administration: Intravenous
Human Endometrial Stromal Cells were treated with non-toxic concentrations of copper ions (0-250 uM). mRNA expressions of insulin-like growth factor binding protein (IGFBP-1), prolactin (PRL), Mn-SOD, and FOXO1 were down-regulated during decidualization following the treatments with 100 or 250 uM copper ions. Meanwhile, the amount of malonaldehyde in the supernatant of cells was increased.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:28:47 GMT 2025
Edited
by admin
on Mon Mar 31 18:28:47 GMT 2025
Record UNII
LRX7AJ16DT
Record Status Validated (UNII)
Record Version
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Name Type Language
CUPRIC SULFATE
II   ORANGE BOOK   USP   VANDF  
Common Name English
COPPER SULFATE PENTAHYDRATE
EP   WHO-DD  
Preferred Name English
CUPRIC SULPHATE PENTAHYDRATE
Common Name English
CUPRUM SULPHURICUM
HPUS  
Common Name English
SULFURIC ACID COPPER(2+) SALT (1:1), HYDRATE (1:5)
Systematic Name English
COPPER(II) SULPHATE PENTAHYDRATE
Systematic Name English
SULFURIC ACID COPPER(2+) SALT (1:1), PENTAHYDRATE
Common Name English
CUPRUM SULPHURICUM [HPUS]
Common Name English
CUPRIC SULFATE PENTAHYDRATE [MI]
Common Name English
COPPER(2+) SULPHATE (1:1) PENTAHYDRATE
Common Name English
Copper(2+) sulfate (1:1) pentahydrate
Common Name English
Copper sulfate pentahydrate [WHO-DD]
Common Name English
COPPER(2+) SULFATE PENTAHYDRATE
Systematic Name English
CUPRIC SULPHATE
Common Name English
CUPRIC SULFATE [VANDF]
Common Name English
COPPER(2+) SULPHATE PENTAHYDRATE
Systematic Name English
COPPER (AS CUPRIC SULFATE)
VANDF  
Common Name English
CUPRIC SULFATE [ORANGE BOOK]
Common Name English
COPPER SULPHATE PENTAHYDRATE
Systematic Name English
CUPRIC SULFATE [II]
Common Name English
COPPER SULFATE [VANDF]
Common Name English
CUPRIC SULFATE PENTAHYDRATE
MI  
Common Name English
COPPER SULFATE PENTAHYDRATE [EP MONOGRAPH]
Common Name English
COPPER (AS CUPRIC SULFATE) [VANDF]
Common Name English
CUPRIC SULFATE [USP MONOGRAPH]
Common Name English
COPPER SULFATE [EP MONOGRAPH]
Common Name English
COPPER (II) SULFATE PENTAHYDRATE
Systematic Name English
COPPER(II) SULFATE PENTAHYDRATE
Systematic Name English
COPPER SULFATE
VANDF  
Systematic Name English
Classification Tree Code System Code
WHO-ATC V03AB20
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
WHO-VATC QV03AB20
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
CFR 21 CFR 184.1261
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
EPA PESTICIDE CODE 24401
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
FDA ORPHAN DRUG 586117
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
Code System Code Type Description
MERCK INDEX
m3913
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY Merck Index
NCI_THESAURUS
C65354
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
ChEMBL
CHEMBL604
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
CHEBI
31440
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
CONCEPT Industrial Aid
CAS
7758-99-8
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
ALANWOOD
copper sulfate
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
CAS
23254-43-5
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
NON-SPECIFIC STOICHIOMETRY
WIKIPEDIA
Cupric sulfate
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
SMS_ID
100000092181
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
RXCUI
21579
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY RxNorm
EVMPD
SUB11846MIG
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
CHEBI
23414
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
DAILYMED
LRX7AJ16DT
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
HSDB
2968
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
EPA CompTox
DTXSID9031066
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
MESH
D019327
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
DRUG CENTRAL
4282
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
EVMPD
SUB13460MIG
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
PUBCHEM
24463
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
DRUG BANK
DB06778
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
FDA UNII
LRX7AJ16DT
Created by admin on Mon Mar 31 18:28:47 GMT 2025 , Edited by admin on Mon Mar 31 18:28:47 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY