Afimkibart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:18:55 GMT 2025` Edited by `admin` on `Wed Apr 02 00:18:55 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	LNU830UGAX
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Afimkibart

Official Name

English

H-gamma1 heavy chain Homo sapiens (1-453) [VH (Homo sapiens IGHV1-18*01 (92.9%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (119), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v14-1 CH2 A1.3, A

Preferred Name

English

afimkibart [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens TNFSF15 (tumor necrosis factor (TNF) superfamily member 15, vascular endothelial cell growth inhibitor, VEGI, VEGI192A, TNF superfamily ligand TL1A)], Homo sapiens monoclonal antibody

Common Name

English

Code System Code Type Description

FDA UNII

LNU830UGAX

Created by admin on Wed Apr 02 00:18:55 GMT 2025 , Edited by admin on Wed Apr 02 00:18:55 GMT 2025

PRIMARY

INN

13205

Created by admin on Wed Apr 02 00:18:55 GMT 2025 , Edited by admin on Wed Apr 02 00:18:55 GMT 2025

PRIMARY

NCI_THESAURUS

C211786

Created by admin on Wed Apr 02 00:18:55 GMT 2025 , Edited by admin on Wed Apr 02 00:18:55 GMT 2025

PRIMARY

SMS_ID

300000043339

Created by admin on Wed Apr 02 00:18:55 GMT 2025 , Edited by admin on Wed Apr 02 00:18:55 GMT 2025

PRIMARY

CAS

2911580-96-4

Created by admin on Wed Apr 02 00:18:55 GMT 2025 , Edited by admin on Wed Apr 02 00:18:55 GMT 2025

PRIMARY

CAS

1822383-56-1

Created by admin on Wed Apr 02 00:18:55 GMT 2025 , Edited by admin on Wed Apr 02 00:18:55 GMT 2025

SUPERSEDED

From	To
1_22	1_96
1_151	1_207
1_227	3_214
1_233	2_233
1_236	2_236
1_268	1_328
1_374	1_432
2_22	2_96
2_151	2_207
2_227	4_214
2_268	2_328
2_374	2_432
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_304
N	2_304

Related Record Type Details


					NO7Z247RXI

TL1A

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					LNU830UGAX

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL