Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H25N7O4 |
| Molecular Weight | 391.4249 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(N\N=C\C2CCCCC2)=NC3=C1N=CN3[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O
InChI
InChIKey=XJFMHMFFBSOEPR-DNZQAUTHSA-N
InChI=1S/C17H25N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h6,8-10,12-13,16,25-27H,1-5,7H2,(H3,18,21,22,23)/b20-6+/t10-,12-,13-,16-/m1/s1
| Molecular Formula | C17H25N7O4 |
| Molecular Weight | 391.4249 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Binodenoson, a selective adenosine A(2A) receptor agonist, was being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging. Binodenoson for injection under the brand name CorVue was developed for use in patients with or at risk for coronary artery disease (CAD) who are unable to perform a cardiac exercise stress test. CorVue was designed to minimize side effects such as dyspnea, flushing, heart block, and chest pain. Binodenoson did not achieve FDA approval in 2009 due to concerns over equivalence of its efficacy with adenosine.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetics and safety of binodenoson after intravenous dose escalation in healthy volunteers. | 2005 Mar-Apr |
|
| A new generation of coronary vasodilators in stress perfusion imaging. | 2007 Jun 1 |
|
| Safety of binodenoson, a selective adenosine A2A receptor agonist vasodilator pharmacological stress agent, in healthy subjects with mild intermittent asthma. | 2009 Nov |
| Substance Class |
Chemical
Created
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admin
on
Edited
Sat Dec 16 17:55:05 UTC 2023
by
admin
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Sat Dec 16 17:55:05 UTC 2023
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LJA4M1L5LG
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C174671
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