U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 08:28:15 GMT 2023
Edited
by admin
on Sat Dec 16 08:28:15 GMT 2023
Protein Type TRANSPORTER
Protein Sub Type ORGANIC ANION
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
LGG1US7EOD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OATL-4
Common Name English
OAT4L
Common Name English
URATE ANION EXCHANGER 1
Common Name English
URAT-1
Common Name English
SLC22A12
Common Name English
RST
Common Name English
OATL4
Common Name English
SOLUTE CARRIER FAMILY 22 MEMBER 12
Common Name English
URAT1
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL SLC22A12
Created by admin on Sat Dec 16 08:28:15 GMT 2023 , Edited by admin on Sat Dec 16 08:28:15 GMT 2023
Code System Code Type Description
UNIPROT
Q96S37
Created by admin on Sat Dec 16 08:28:15 GMT 2023 , Edited by admin on Sat Dec 16 08:28:15 GMT 2023
PRIMARY
FDA UNII
LGG1US7EOD
Created by admin on Sat Dec 16 08:28:15 GMT 2023 , Edited by admin on Sat Dec 16 08:28:15 GMT 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_56
N 1_102
Related Record Type Details
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
Primary target.
SUBSTRATE -> TRANSPORTER
In the human kidney, urate is transported (reabsorbed) via URAT1 across the apical membrane of proximal tubule cells, in exchange for anions being transported back into the tubule lumen to maintain electrical balance.
INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL