OATL-4

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 08:28:15 GMT 2023` Edited by `admin` on `Sat Dec 16 08:28:15 GMT 2023`
Protein Type	TRANSPORTER
Protein Sub Type	ORGANIC ANION
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	LGG1US7EOD
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OATL-4

Common Name

English

OAT4L

Common Name

English

URATE ANION EXCHANGER 1

Common Name

English

URAT-1

Common Name

English

SLC22A12

Common Name

English

RST

Common Name

English

OATL4

Common Name

English

SOLUTE CARRIER FAMILY 22 MEMBER 12

Common Name

English

URAT1

Common Name

English

Classification Tree Code System Code

UCSF-FDA TRANSPORTAL

SLC22A12

Created by admin on Sat Dec 16 08:28:15 GMT 2023 , Edited by admin on Sat Dec 16 08:28:15 GMT 2023

Code System Code Type Description

UNIPROT

Q96S37

Created by admin on Sat Dec 16 08:28:15 GMT 2023 , Edited by admin on Sat Dec 16 08:28:15 GMT 2023

PRIMARY

FDA UNII

LGG1US7EOD

Created by admin on Sat Dec 16 08:28:15 GMT 2023 , Edited by admin on Sat Dec 16 08:28:15 GMT 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_56
N	1_102

Related Record Type Details


					09ERP08I3W

LESINURAD

INHIBITOR -> TRANSPORTER

Amount:


					PO572Z7917

PROBENECID

INHIBITOR -> TRANSPORTER

Amount:


					KQS6TFS7JY

Puliginurad

INHIBITOR -> TARGET

Amount:


					WT8RGZ52JT

(2S,3S,4S,5R,6S)-6-(2-((3-(4-CYANO-1-NAPHTHYL)-4-PYRIDYL)SULFANYL)-2-METHYL-PROPANOYL)OXY-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					EWR4G9V8JG

Arhalofenic Acid

INHIBITOR -> TARGET

Amount:


					09ERP08I3W

LESINURAD

INHIBITOR -> TARGET

Amount:


					66VLQ6E6DL

PRATOSARTAN

INHIBITOR -> TRANSPORTER

Amount:


					BGF9MN2HU1

FENOFIBRIC ACID

INHIBITOR -> TRANSPORTER

Amount:


					V6OFU47K3W

SULFINPYRAZONE

INHIBITOR -> TRANSPORTER

Amount:


					JMS50MPO89

LOSARTAN

INHIBITOR -> TRANSPORTER

Amount:


					4M7NUR5V9E

6-Hydroxybenzbromarone

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

305EB53128

DOTINURAD

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					12WJ62D047

VERINURAD

INHIBITOR -> TARGET

Amount:


					4POG0RL69O

BENZBROMARONE

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					PO572Z7917

PROBENECID

INHIBITOR -> TARGET

Comments:

Primary target.

Amount:


					268B43MJ25

URIC ACID

SUBSTRATE -> TRANSPORTER

Comments:

In the human kidney, urate is transported (reabsorbed) via URAT1 across the apical membrane of proximal tubule cells, in exchange for anions being transported back into the tubule lumen to maintain electrical balance.

Amount: