NEPINALONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H25NO
Molecular Weight	271.3972
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC2(CCN1CCCCC1)C(=O)CCC3=C2C=CC=C3

InChI

InChIKey=RVXGRCNWGOHSDE-UHFFFAOYSA-N

InChI=1S/C18H25NO/c1-18(11-14-19-12-5-2-6-13-19)16-8-4-3-7-15(16)9-10-17(18)20/h3-4,7-8H,2,5-6,9-14H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H25NO
Molecular Weight	271.3972
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22711801 | https://www.codifa.it/farmaci/n/nepituss-nepinalone-antitussivi | https://moh-it.pure.elsevier.com/en/publications/antitussive-activity-of-l-and-d-isomers-of-nepinalone-vs-racemus-

Nepinalone is a new alchilaminate derivative of β-tetralone, which possess a non-opioid antitussive activity. Nepinalone racemus exerted a significant antitussive activity and both L- and D-isomers confirmed to possess a significant dose-correlated antitussive effect with better trend of activity for D-isomer, but not statistically significant. It was predicted to act via sigma receptors. Occasionally, episodes of gastric intolerance have been reported and rapidly receded when treatment was stopped. The use of doses higher than those recommended could cause drowsiness.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Single dose - 2, 4, 8 mg/kg

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:05:45 GMT 2023` Edited by `admin` on `Fri Dec 15 16:05:45 GMT 2023`
Record UNII	L9806LPR7G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEPINALONE

Official Name

English

NEPINALONE [MART.]

Common Name

English

Nepinalone [WHO-DD]

Common Name

English

(±)-3,4-DIHYDRO-1-METHYL-1-(2-PIPERIDINOETHYL)-2(1H)-NAPHTHALENONE

Systematic Name

English

nepinalone [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QR05DB26