NEPINALONE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H25NO.ClH
Molecular Weight	307.858
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC2(CCN1CCCCC1)C(=O)CCC3=C2C=CC=C3

InChI

InChIKey=DWXUSWVHSCQVTM-UHFFFAOYSA-N

InChI=1S/C18H25NO.ClH/c1-18(11-14-19-12-5-2-6-13-19)16-8-4-3-7-15(16)9-10-17(18)20;/h3-4,7-8H,2,5-6,9-14H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H25NO
Molecular Weight	271.3972
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22711801 | https://www.codifa.it/farmaci/n/nepituss-nepinalone-antitussivi | https://moh-it.pure.elsevier.com/en/publications/antitussive-activity-of-l-and-d-isomers-of-nepinalone-vs-racemus-

Nepinalone is a new alchilaminate derivative of β-tetralone, which possess a non-opioid antitussive activity. Nepinalone racemus exerted a significant antitussive activity and both L- and D-isomers confirmed to possess a significant dose-correlated antitussive effect with better trend of activity for D-isomer, but not statistically significant. It was predicted to act via sigma receptors. Occasionally, episodes of gastric intolerance have been reported and rapidly receded when treatment was stopped. The use of doses higher than those recommended could cause drowsiness.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Single dose - 2, 4, 8 mg/kg

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:05:50 GMT 2025` Edited by `admin` on `Mon Mar 31 21:05:50 GMT 2025`
Record UNII	68J256455O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEPINALONE HYDROCHLORIDE

Common Name

English

2(1H)-NAPHTHALENONE, 3,4-DIHYDRO-1-METHYL-1-(2-(1-PIPERIDINYL)ETHYL)-, HYDROCHLORIDE (1:1)

Preferred Name

English

Nepinalone Hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

100000093025