Ramantamig

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:41:36 GMT 2025` Edited by `admin` on `Wed Apr 02 19:41:36 GMT 2025`
Protein Type	TRISPECIFIC ANTIBODY
Protein Sub Type	IGG1\|LAMDA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	L97FGF546Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain anti-CD3E fused to a scFvkh anti-GPRC5D (1-721) [Hgamma1 heavy chain anti-CD3E Homo sapiens (1-450) [VH (Homo sapiens IGHV6-1*01 (88.1%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [10.9.10] (26-35.53-61.100-109)) (1-120)-Homo sapiens IGHG1*0

Preferred Name

English

Ramantamig

Official Name

English

Immunoglobulin G1, trispecific, [237-alanine,238-alanine,268-serine,369-serine,371-alanine,410-valine,438-arginine,439-phenylalanine], anti-(human CD3 antigen ?-chain) (human monoclonal BGCB491 ?1-chain) fusion protein with peptide linker (GGGGS)4 fusion

Common Name

English

immunoglobulin (H-gamma1-scFvkh_L-lambda2)_scFvkh-G1(h-CH2-CH3), anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], anti-[Homo sapiens GPRC5D (G protein-coupled receptor class C group 5 member D)] and anti-[Homo sapiens TNFRSF17 (tumor necrosis factor (TNF)

Common Name

English

ramantamig [INN]

Common Name

English

Code System Code Type Description

INN

13340

Created by admin on Wed Apr 02 19:41:36 GMT 2025 , Edited by admin on Wed Apr 02 19:41:36 GMT 2025

PRIMARY

CAS

2988886-91-3

Created by admin on Wed Apr 02 19:41:36 GMT 2025 , Edited by admin on Wed Apr 02 19:41:36 GMT 2025

PRIMARY

FDA UNII

L97FGF546Q

Created by admin on Wed Apr 02 19:41:36 GMT 2025 , Edited by admin on Wed Apr 02 19:41:36 GMT 2025

PRIMARY

From	To
3_138	3_197
3_22	3_90
2_404	2_462
2_298	2_358
2_151	2_225
2_23	2_89
1_624	1_699
1_493	1_563
1_370	1_428
1_264	1_324
1_232	2_266
1_229	2_263
1_223	3_215
1_147	1_203
1_22	1_99

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_334

Related Record Type Details


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->LIGAND

Amount:


					5N4BM61CX9

G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER D

TARGET->LIGAND

Amount:

Related Record Type Details


					L97FGF546Q

Ramantamig

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [3_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[2_484]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL