CARPRONIUM CHLORIDE MONOHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H18NO2.Cl.H2O
Molecular Weight	213.702
Optical Activity	NONE
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CARPRONIUM CHLORIDE MONOHYDRATE

Structure Search

SMILES

O.[Cl-].COC(=O)CCC[N+](C)(C)C

InChI

InChIKey=HUCARLCBGJLGMH-UHFFFAOYSA-M

InChI=1S/C8H18NO2.ClH.H2O/c1-9(2,3)7-5-6-8(10)11-4;;/h5-7H2,1-4H3;1H;1H2/q+1;;/p-1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C8H18NO2
Molecular Weight	160.234
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/16543627
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/22171995 and http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602

Carpronium chloride is a hair growth reagent with a vasodilatory action. In vivo studies indicated that carpronium chloride achieved dilatation of vascular smooth muscle in the microcirculation of rats. FUROZIN SOLUTION 5% (active ingredient Carpronium chloride) has local vasodilating effect and hair growth stimulatory effect to improve alopecia and vitiligo. It is usually used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 162 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01175	Agonist 2752

Conditions

Condition	Modality	Highest Phase	Product
Hair loss 5 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Preventing	Approved 8583	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Seborrhea sicca 3 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Primary	Approved 8583	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Vitiligo 9 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602	Primary	Approved 8583	FUROZIN SOLUTION 5% Approved Use Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.

Doses

Dose	Population	Adverse events
4500 mg single, oral Accidental dose Dose: 4500 mg Route: oral Route: single Dose: 4500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	Other AEs: Vomiting, Hot flush... Other AEs: Vomiting Hot flush Sweating Salivation Hypotension Bradycardia Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/

AEs

AE	Dose	Population
Bradycardia	4500 mg single, oral Accidental dose Dose: 4500 mg Route: oral Route: single Dose: 4500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/
Hot flush	4500 mg single, oral Accidental dose Dose: 4500 mg Route: oral Route: single Dose: 4500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/
Hypotension	4500 mg single, oral Accidental dose Dose: 4500 mg Route: oral Route: single Dose: 4500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/
Salivation	4500 mg single, oral Accidental dose Dose: 4500 mg Route: oral Route: single Dose: 4500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/
Sweating	4500 mg single, oral Accidental dose Dose: 4500 mg Route: oral Route: single Dose: 4500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/
Vomiting	4500 mg single, oral Accidental dose Dose: 4500 mg Route: oral Route: single Dose: 4500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/34030906/

PubMed

Title	Date	PubMed
Topical immunotherapy in alopecia areata.	2010-01	21188022
Effects of carpronium chloride on the microvascular blood flow in rat mesentery using intravital videomicroscopy.	2006	16543627
Study of active substances involved in skin dysfunction induced by crowding stress. I. Effect of crowding and isolation on some physiological variables, skin function and skin blood perfusion in hairless mice.	2003-02	12576676
Seventeen cases of alopecia areata: combination of SADBE topical immunotherapy with other therapies.	2002-10	12433000

Patents

Sample Use Guides

In Vivo Use Guide

For alopecia and seborrhea sicca: In general, apply appropriate amount of the medicine to the affected area; or sprinkle the medicine on the whole scalp; twice to 3 times daily, and gently massage the head. For vitiligo vulgaris: In general, apply appropriate amount of the medicine to the affected area, 3 to 4 times daily.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:29:28 GMT 2025` Edited by `admin` on `Mon Mar 31 21:29:28 GMT 2025`
Record UNII	L4864ASJ91
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARPRONIUM CHLORIDE MONOHYDRATE

Common Name

English

CARPRONIUM CHLORIDE HYDRATE

Preferred Name

English

1-BUTANAMINIUM, 4-METHOXY-N,N,N-TRIMETHYL-4-OXO-, CHLORIDE, HYDRATE (1:1:1)

Systematic Name

English

1-BUTANAMINIUM, 4-METHOXY-N,N,N-TRIMETHYL-4-OXO-, CHLORIDE, MONOHYDRATE

Systematic Name

English

CARPRONIUM CHLORIDE HYDRATE [JAN]

Common Name

English

Code System Code Type Description

FDA UNII

L4864ASJ91