DATELLIPTIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H28N3O
Molecular Weight	362.4879
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CC[N+]1=CC2=C(C)C3=C(NC4=CC=C(O)C=C34)C(C)=C2C=C1

InChI

InChIKey=NGOHTJBYABHJKF-UHFFFAOYSA-O

InChI=1S/C23H27N3O/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23/h7-10,13-14,27H,5-6,11-12H2,1-4H3/p+1

HIDE SMILES / InChI

Molecular Formula	C23H27N3O
Molecular Weight	361.48
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2177044 | https://www.ncbi.nlm.nih.gov/pubmed/1628372

Datelliptium is a DNA-intercalating agent, an analog of a natural alkaloid ellipticine. The compound was active in vivo against a variety of murine solid tumors. In a phase I clinical trial no objective complete or partial responses were observed in patients with solid tumors or lymphoma treated with datelliptium.

Approval Year

PubMed

Title	Date	PubMed
Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice.	1990 Aug	2177044
Phase I study of Datelliptium chloride, hydrochloride given by 24-h continuous intravenous infusion.	1992	1628372

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:29:28 GMT 2023` Edited by `admin` on `Fri Dec 15 15:29:28 GMT 2023`
Record UNII	L374Y6WE0D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DATELLIPTIUM

Common Name

English

2-(2-(DIETHYLAMINO)ETHYL)-9-HYDROXY-5,11-DIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLIUM

Systematic Name

English

DATELLIPTIUM ION

Common Name

English

DATELLIPTIUM CATION

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C582