DATELLIPTIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H28N3O
Molecular Weight	362.4879
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CC[N+]1=CC2=C(C)C3=C(NC4=C3C=C(O)C=C4)C(C)=C2C=C1

InChI

InChIKey=NGOHTJBYABHJKF-UHFFFAOYSA-O

InChI=1S/C23H27N3O/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23/h7-10,13-14,27H,5-6,11-12H2,1-4H3/p+1

HIDE SMILES / InChI

Molecular Formula	C23H27N3O
Molecular Weight	361.48
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2177044 | https://www.ncbi.nlm.nih.gov/pubmed/1628372

Datelliptium is a DNA-intercalating agent, an analog of a natural alkaloid ellipticine. The compound was active in vivo against a variety of murine solid tumors. In a phase I clinical trial no objective complete or partial responses were observed in patients with solid tumors or lymphoma treated with datelliptium.

Approval Year

PubMed

Title	Date	PubMed
Phase I study of Datelliptium chloride, hydrochloride given by 24-h continuous intravenous infusion.	1992	1628372
Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice.	1990-08	2177044

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:58:54 GMT 2025` Edited by `admin` on `Mon Mar 31 17:58:54 GMT 2025`
Record UNII	L374Y6WE0D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DATELLIPTIUM

Common Name

English

DATELLIPTIUM CATION

Preferred Name

English

2-(2-(DIETHYLAMINO)ETHYL)-9-HYDROXY-5,11-DIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLIUM

Systematic Name

English

DATELLIPTIUM ION

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C582