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Details

Stereochemistry ACHIRAL
Molecular Formula C23H28N3O.Cl
Molecular Weight 397.941
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DATELLIPTIUM CHLORIDE

SMILES

[Cl-].CCN(CC)CC[N+]1=CC2=C(C)C3=C(NC4=CC=C(O)C=C34)C(C)=C2C=C1

InChI

InChIKey=UCICRVXYPSKKJK-UHFFFAOYSA-N
InChI=1S/C23H27N3O.ClH/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23;/h7-10,13-14,27H,5-6,11-12H2,1-4H3;1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C23H27N3O
Molecular Weight 361.48
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Datelliptium is a DNA-intercalating agent, an analog of a natural alkaloid ellipticine. The compound was active in vivo against a variety of murine solid tumors. In a phase I clinical trial no objective complete or partial responses were observed in patients with solid tumors or lymphoma treated with datelliptium.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice.
1990 Aug
Phase I study of Datelliptium chloride, hydrochloride given by 24-h continuous intravenous infusion.
1992
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:16:05 GMT 2023
Edited
by admin
on Fri Dec 15 16:16:05 GMT 2023
Record UNII
V5QKF7Q20O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DATELLIPTIUM CHLORIDE
INN  
INN  
Official Name English
2-(2-(DIETHYLAMINO)ETHYL)-9-HYDROXY-5,11-DIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLIUM CHLORIDE
Systematic Name English
datelliptium chloride [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C582
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
Code System Code Type Description
MESH
C060073
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
INN
5983
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
EPA CompTox
DTXSID80909340
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
NCI_THESAURUS
C76759
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
ChEMBL
CHEMBL197585
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
CAS
105118-14-7
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
PUBCHEM
72034
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
SMS_ID
100000083444
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
EVMPD
SUB06916MIG
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
FDA UNII
V5QKF7Q20O
Created by admin on Fri Dec 15 16:16:05 GMT 2023 , Edited by admin on Fri Dec 15 16:16:05 GMT 2023
PRIMARY
Related Record Type Details
Structure of DATELLIPTIUM
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DATELLIPTIUM
ACTIVE MOIETY
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