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Details

Stereochemistry ACHIRAL
Molecular Formula C23H28N3O.Cl
Molecular Weight 397.941
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DATELLIPTIUM CHLORIDE

SMILES

[Cl-].CCN(CC)CC[N+]1=CC2=C(C)C3=C(NC4=C3C=C(O)C=C4)C(C)=C2C=C1

InChI

InChIKey=UCICRVXYPSKKJK-UHFFFAOYSA-N
InChI=1S/C23H27N3O.ClH/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23;/h7-10,13-14,27H,5-6,11-12H2,1-4H3;1H

HIDE SMILES / InChI
Molecular Formula C23H27N3O
Molecular Weight 361.48
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Datelliptium is a DNA-intercalating agent, an analog of a natural alkaloid ellipticine. The compound was active in vivo against a variety of murine solid tumors. In a phase I clinical trial no objective complete or partial responses were observed in patients with solid tumors or lymphoma treated with datelliptium.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Phase I study of Datelliptium chloride, hydrochloride given by 24-h continuous intravenous infusion.
1992
Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice.
1990-08
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:23:30 GMT 2025
Edited
by admin
on Mon Mar 31 18:23:30 GMT 2025
Record UNII
V5QKF7Q20O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DATELLIPTIUM CHLORIDE
INN  
INN  
Official Name English
datelliptium chloride [INN]
Preferred Name English
2-(2-(DIETHYLAMINO)ETHYL)-9-HYDROXY-5,11-DIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLIUM CHLORIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C582
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
Code System Code Type Description
MESH
C060073
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
INN
5983
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
EPA CompTox
DTXSID80909340
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
NCI_THESAURUS
C76759
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
ChEMBL
CHEMBL197585
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
CAS
105118-14-7
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
PUBCHEM
72034
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
SMS_ID
100000083444
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
EVMPD
SUB06916MIG
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
FDA UNII
V5QKF7Q20O
Created by admin on Mon Mar 31 18:23:30 GMT 2025 , Edited by admin on Mon Mar 31 18:23:30 GMT 2025
PRIMARY
Related Record Type Details
Structure of DATELLIPTIUM
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DATELLIPTIUM
ACTIVE MOIETY
NIH
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