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Details

Stereochemistry ACHIRAL
Molecular Formula C17H22N2OS
Molecular Weight 302.434
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NETICONAZOLE

SMILES

CCCCCOC1=C(C=CC=C1)C(=C/SC)\N2C=CN=C2

InChI

InChIKey=VWOIKFDZQQLJBJ-DTQAZKPQSA-N
InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+

HIDE SMILES / InChI
Molecular Formula C17H22N2OS
Molecular Weight 302.434
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description
Sources: Ludwig Zirngibl. Antifungal Azoles: A Comprehensive Survey of their Structures and Properties. 1998 Wiley-VCH Verlag GmbH ISBN: 3-527-29487-2 DOI: 10.1002/3527602682 p.83

Neticonazole is an antifungal drug. It is especially active against Candida glabrata, Trichophyton, Microsporum, Aspergillus and Fonsecaea spp. Clinical experience demonstrated neticonazole as a safe and effective treatment of mycoses like trichophytosis, candidiasis, and different types of tinea.

Originator

SS Pharmaceutical
3
Sources: Ludwig Zirngibl. Antifungal Azoles: A Comprehensive Survey of their Structures and Properties. 1998 Wiley-VCH Verlag GmbH ISBN: 3-527-29487-2 DOI: 10.1002/3527602682 p.83

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
Atolant

Approved Use

Neticonazole is used as a topical ointment in Japan under the tradename Atolant for treatment of mycoses.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
5.9 ng/mL
OTHER GOV'T
https://www.info.pmda.go.jp/go/interview/4/650034_2655711M1039_4_111_1F.pdf#page=26
100 mg single, topical
dose: 100 mg
route of administration: Topical
experiment type: SINGLE
co-administered:
NETICONAZOLE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
63.3 ng × h/mL
OTHER GOV'T
https://www.info.pmda.go.jp/go/interview/4/650034_2655711M1039_4_111_1F.pdf#page=26
100 mg single, topical
dose: 100 mg
route of administration: Topical
experiment type: SINGLE
co-administered:
NETICONAZOLE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
7.63 h
OTHER GOV'T
https://www.info.pmda.go.jp/go/interview/4/650034_2655711M1039_4_111_1F.pdf#page=26
100 mg single, topical
dose: 100 mg
route of administration: Topical
experiment type: SINGLE
co-administered:
NETICONAZOLE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1 % 1 times / day multiple, topical
Recommended
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/8734665/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/8734665/
Other AEs: Pruritus, Contact dermatitis...
Other AEs:
Pruritus (0.8%)
Contact dermatitis (0.8%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/8734665/
1 % 1 times / day multiple, topical
Recommended
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/9330830/
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/9330830/
Other AEs: contact dermatiti...
Other AEs:
contact dermatiti
Sources:
https://pubmed.ncbi.nlm.nih.gov/9330830/
1 % 1 times / day multiple, topical
Recommended
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/9062749/
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/9062749/
Other AEs: Contact dematitis...
Other AEs:
Contact dematitis
Sources:
https://pubmed.ncbi.nlm.nih.gov/9062749/
AEs

AEs

AESignificanceDosePopulation
Contact dermatitis 0.8%
1 % 1 times / day multiple, topical
Recommended
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/8734665/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/8734665/
Pruritus 0.8%
1 % 1 times / day multiple, topical
Recommended
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/8734665/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/8734665/
contact dermatiti
1 % 1 times / day multiple, topical
Recommended
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/9330830/
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/9330830/
Contact dematitis
1 % 1 times / day multiple, topical
Recommended
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/9062749/
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/9062749/
PubMed

PubMed

TitleDatePubMed
Effects of antifungal drugs on proliferation signals in Candida albicans.
2006-05
Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan.
2001-08
[Therapeutic efficacies of neticonazole (SS717) cream and solution in experimental cutaneous Candida albicans infection of guinea pigs].
1993-10
Patents

Patents

EP1568366A1
2
JP2004083439A
2
JP2005170913A
2
JPH0820527A
3
US20050186161
2

Sample Use Guides

In Vivo Use Guide
1% cream applied once a day on the affected and surrounding area.
Route of Administration: Topical
In Vitro Use Guide
antifungal activity of Neticonazole at 1 ug/ml
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:32:21 GMT 2025
Edited
by admin
on Mon Mar 31 18:32:21 GMT 2025
Record UNII
KVL61ZF9UO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
(E)-1-(2-(METHYLTHIO)-1-(O-(PENTYLOXY)PHENYL)VINYL)IMIDAZOLE
Preferred Name English
NETICONAZOLE
INN   MI   WHO-DD  
INN  
Official Name English
Neticonazole [WHO-DD]
Common Name English
neticonazole [INN]
Common Name English
NETICONAZOLE [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C514
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
Code System Code Type Description
ChEMBL
CHEMBL2107447
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
WIKIPEDIA
NETICONAZOLE
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
DRUG CENTRAL
1902
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
FDA UNII
KVL61ZF9UO
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
INN
6613
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
CHEBI
135281
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
SMS_ID
100000079988
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
MESH
C084784
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
EPA CompTox
DTXSID4057633
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
CAS
130726-68-0
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
EVMPD
SUB14639MIG
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
PUBCHEM
5282433
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
MERCK INDEX
m7833
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY Merck Index
NCI_THESAURUS
C66235
Created by admin on Mon Mar 31 18:32:21 GMT 2025 , Edited by admin on Mon Mar 31 18:32:21 GMT 2025
PRIMARY
Related Record Type Details
Structure of ERGOSTEROL
TARGET -> INHIBITOR
Structure of NETICONAZOLE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of NETICONAZOLE
ACTIVE MOIETY
NIH
NCATS
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