NETICONAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H22N2OS
Molecular Weight	302.434
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCOC1=C(C=CC=C1)C(=C/SC)\N2C=CN=C2

InChI

InChIKey=VWOIKFDZQQLJBJ-DTQAZKPQSA-N

InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+

HIDE SMILES / InChI

Molecular Formula	C17H22N2OS
Molecular Weight	302.434
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: Ludwig Zirngibl. Antifungal Azoles: A Comprehensive Survey of their Structures and Properties. 1998 Wiley-VCH Verlag GmbH ISBN: 3-527-29487-2 DOI: 10.1002/3527602682 p.83

Neticonazole is an antifungal drug. It is especially active against Candida glabrata, Trichophyton, Microsporum, Aspergillus and Fonsecaea spp. Clinical experience demonstrated neticonazole as a safe and effective treatment of mycoses like trichophytosis, candidiasis, and different types of tinea.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ergosterol biosynthetic process 2 Target ID: GO:0006696 Sources: http://www.ncbi.nlm.nih.gov/pubmed/11516941	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mycoses 12 Sources: DOI: 10.1002/3527602682.ch3 http://fmedicine.ajums.ac.ir/_fmedicine/documents/Antifungal_Azoles_A_Comprehensi_20130413_160839.pdf	Curative		Approved 8429	Atolant Approved Use Neticonazole is used as a topical ointment in Japan under the tradename Atolant for treatment of mycoses.

PubMed

Title	Date	PubMed
[Therapeutic efficacies of neticonazole (SS717) cream and solution in experimental cutaneous Candida albicans infection of guinea pigs].	1993 Oct	8254891
Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan.	2001 Aug	11516941
Effects of antifungal drugs on proliferation signals in Candida albicans.	2006 May	16651719

Patents

Sample Use Guides

In Vivo Use Guide

1% cream applied once a day on the affected and surrounding area.

Route of Administration: Topical

In Vitro Use Guide

antifungal activity of Neticonazole at 1 ug/ml

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:36:17 UTC 2023` Edited by `admin` on `Fri Dec 15 16:36:17 UTC 2023`
Record UNII	KVL61ZF9UO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NETICONAZOLE

Official Name

English

(E)-1-(2-(METHYLTHIO)-1-(O-(PENTYLOXY)PHENYL)VINYL)IMIDAZOLE

Common Name

English

Neticonazole [WHO-DD]

Common Name

English

neticonazole [INN]

Common Name

English

NETICONAZOLE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C514