NETICONAZOLE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H22N2OS.ClH
Molecular Weight	338.895
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCCCOC1=C(C=CC=C1)C(=C/SC)\N2C=CN=C2

InChI

InChIKey=HAHMABKERDVYCH-ZUQRMPMESA-N

InChI=1S/C17H22N2OS.ClH/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19;/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3;1H/b16-13+;

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H22N2OS
Molecular Weight	302.434
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: Ludwig Zirngibl. Antifungal Azoles: A Comprehensive Survey of their Structures and Properties. 1998 Wiley-VCH Verlag GmbH ISBN: 3-527-29487-2 DOI: 10.1002/3527602682 p.83

Neticonazole is an antifungal drug. It is especially active against Candida glabrata, Trichophyton, Microsporum, Aspergillus and Fonsecaea spp. Clinical experience demonstrated neticonazole as a safe and effective treatment of mycoses like trichophytosis, candidiasis, and different types of tinea.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ergosterol biosynthetic process 2 Target ID: GO:0006696 Sources: http://www.ncbi.nlm.nih.gov/pubmed/11516941	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mycoses 12 Sources: DOI: 10.1002/3527602682.ch3 http://fmedicine.ajums.ac.ir/_fmedicine/documents/Antifungal_Azoles_A_Comprehensi_20130413_160839.pdf	Curative		Approved 8429	Atolant Approved Use Neticonazole is used as a topical ointment in Japan under the tradename Atolant for treatment of mycoses.

PubMed

Title	Date	PubMed
[Therapeutic efficacies of neticonazole (SS717) cream and solution in experimental cutaneous Candida albicans infection of guinea pigs].	1993 Oct	8254891
Effects of antifungal drugs on proliferation signals in Candida albicans.	2006 May	16651719

Patents

Sample Use Guides

In Vivo Use Guide

1% cream applied once a day on the affected and surrounding area.

Route of Administration: Topical

In Vitro Use Guide

antifungal activity of Neticonazole at 1 ug/ml

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:24:56 GMT 2023` Edited by `admin` on `Fri Dec 15 16:24:56 GMT 2023`
Record UNII	PKF582ZH6P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NETICONAZOLE HYDROCHLORIDE

Common Name

English

SS-717

Code

English

NETICONAZOLE HYDROCHLORIDE [MART.]

Common Name

English

SS 717

Code

English

NETICONAZOLE HYDROCHLORIDE [JAN]

Common Name

English

Neticonazole hydrochloride [WHO-DD]

Common Name

English

1-((E)-1-(2-AMOXYPHENYL)-2-(METHYLTHIO)VINYL)IMIDAZOLE HYDROCHLORIDE

Systematic Name

English

NETICONAZOLE HYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

SMS_ID

100000085735