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Details

Stereochemistry ACHIRAL
Molecular Formula C17H22N2OS.ClH
Molecular Weight 338.895
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NETICONAZOLE HYDROCHLORIDE

SMILES

Cl.CCCCCOC1=C(C=CC=C1)C(=C/SC)\N2C=CN=C2

InChI

InChIKey=HAHMABKERDVYCH-ZUQRMPMESA-N
InChI=1S/C17H22N2OS.ClH/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19;/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3;1H/b16-13+;

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C17H22N2OS
Molecular Weight 302.434
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Neticonazole is an antifungal drug. It is especially active against Candida glabrata, Trichophyton, Microsporum, Aspergillus and Fonsecaea spp. Clinical experience demonstrated neticonazole as a safe and effective treatment of mycoses like trichophytosis, candidiasis, and different types of tinea.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Atolant

Cmax

ValueDoseCo-administeredAnalytePopulation
5.9 ng/mL
100 mg single, topical
NETICONAZOLE plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
63.3 ng × h/mL
100 mg single, topical
NETICONAZOLE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
7.63 h
100 mg single, topical
NETICONAZOLE plasma
Homo sapiens

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
1% cream applied once a day on the affected and surrounding area.
Route of Administration: Topical
In Vitro Use Guide
antifungal activity of Neticonazole at 1 ug/ml
Substance Class Chemical
Record UNII
PKF582ZH6P
Record Status Validated (UNII)
Record Version