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Details

Stereochemistry ACHIRAL
Molecular Formula C23H26N4O5S
Molecular Weight 470.541
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZD-1283

SMILES

CCOC(=O)C1=C(C)N=C(N2CCC(CC2)C(=O)NS(=O)(=O)CC3=CC=CC=C3)C(=C1)C#N

InChI

InChIKey=NEMHKCNXXRQYRF-UHFFFAOYSA-N
InChI=1S/C23H26N4O5S/c1-3-32-23(29)20-13-19(14-24)21(25-16(20)2)27-11-9-18(10-12-27)22(28)26-33(30,31)15-17-7-5-4-6-8-17/h4-8,13,18H,3,9-12,15H2,1-2H3,(H,26,28)

HIDE SMILES / InChI
Molecular Formula C23H26N4O5S
Molecular Weight 470.541
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

AZD-1283 is an antagonist of P2Y12 receptor which was developed by AstraZeneca for the treatment of arterial thrombosis. The drug was tested in pre-clinical studies, however its develoment was terminated.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
P2Y purinoceptor 12
5
Target ID: Q9H244
Gene ID: 64805.0
Gene Symbol: P2RY12
Target Organism: Homo sapiens (Human)
Antagonist
2778
 31.5 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor.
2013 Nov
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
2013 Sep 12
Structure of the human P2Y12 receptor in complex with an antithrombotic drug.
2014 May 1
Patents

Patents

WO2008085118 A1
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 19:10:33 GMT 2023
Edited
by admin
on Sat Dec 16 19:10:33 GMT 2023
Record UNII
KDT372MQ8M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZD-1283
Code English
3-PYRIDINECARBOXYLIC ACID, 5-CYANO-2-METHYL-6-(4-((((PHENYLMETHYL)SULFONYL)AMINO)CARBONYL)-1-PIPERIDINYL)-, ETHYL ESTER
Systematic Name English
Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Systematic Name English
AZD1283
Code English
6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester
Systematic Name English
Code System Code Type Description
FDA UNII
KDT372MQ8M
Created by admin on Sat Dec 16 19:10:33 GMT 2023 , Edited by admin on Sat Dec 16 19:10:33 GMT 2023
PRIMARY
PUBCHEM
23649325
Created by admin on Sat Dec 16 19:10:33 GMT 2023 , Edited by admin on Sat Dec 16 19:10:33 GMT 2023
PRIMARY
CAS
919351-41-0
Created by admin on Sat Dec 16 19:10:33 GMT 2023 , Edited by admin on Sat Dec 16 19:10:33 GMT 2023
PRIMARY
Related Record Type Details
P2Y PURINOCEPTOR 12
TARGET -> INHIBITOR
Related Record Type Details
Structure of AZD-1283
ACTIVE MOIETY
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