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Details

Stereochemistry ACHIRAL
Molecular Formula C23H26N4O5S
Molecular Weight 470.541
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZD-1283

SMILES

CCOC(=O)C1=C(C)N=C(N2CCC(CC2)C(=O)NS(=O)(=O)CC3=CC=CC=C3)C(=C1)C#N

InChI

InChIKey=NEMHKCNXXRQYRF-UHFFFAOYSA-N
InChI=1S/C23H26N4O5S/c1-3-32-23(29)20-13-19(14-24)21(25-16(20)2)27-11-9-18(10-12-27)22(28)26-33(30,31)15-17-7-5-4-6-8-17/h4-8,13,18H,3,9-12,15H2,1-2H3,(H,26,28)

HIDE SMILES / InChI
Molecular Formula C23H26N4O5S
Molecular Weight 470.541
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

AZD-1283 is an antagonist of P2Y12 receptor which was developed by AstraZeneca for the treatment of arterial thrombosis. The drug was tested in pre-clinical studies, however its develoment was terminated.

Originator

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
P2Y purinoceptor 12
5
Target ID: Q9H244
Gene ID: 64805.0
Gene Symbol: P2RY12
Target Organism: Homo sapiens (Human)
Antagonist
2849
 31.5 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Structure of the human P2Y12 receptor in complex with an antithrombotic drug.
2014-05-01
5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor.
2013-11
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
2013-09-12
Patents

Patents

WO2008085118 A1
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Apr 02 13:52:00 GMT 2025
Edited
by admin
on Wed Apr 02 13:52:00 GMT 2025
Record UNII
KDT372MQ8M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZD1283
Preferred Name English
AZD-1283
Code English
3-PYRIDINECARBOXYLIC ACID, 5-CYANO-2-METHYL-6-(4-((((PHENYLMETHYL)SULFONYL)AMINO)CARBONYL)-1-PIPERIDINYL)-, ETHYL ESTER
Systematic Name English
Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Systematic Name English
6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester
Systematic Name English
Code System Code Type Description
FDA UNII
KDT372MQ8M
Created by admin on Wed Apr 02 13:52:00 GMT 2025 , Edited by admin on Wed Apr 02 13:52:00 GMT 2025
PRIMARY
PUBCHEM
23649325
Created by admin on Wed Apr 02 13:52:00 GMT 2025 , Edited by admin on Wed Apr 02 13:52:00 GMT 2025
PRIMARY
CAS
919351-41-0
Created by admin on Wed Apr 02 13:52:00 GMT 2025 , Edited by admin on Wed Apr 02 13:52:00 GMT 2025
PRIMARY
Related Record Type Details
P2Y PURINOCEPTOR 12
TARGET -> INHIBITOR
Related Record Type Details
Structure of AZD-1283
ACTIVE MOIETY
NIH
NCATS
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