MEFENOREX

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H18ClN
Molecular Weight	211.731
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CC1=CC=CC=C1)NCCCCl

InChI

InChIKey=XXVROGAVTTXONC-UHFFFAOYSA-N

InChI=1S/C12H18ClN/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,8-10H2,1H3

HIDE SMILES / InChI

Molecular Formula	C12H18ClN
Molecular Weight	211.731
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3743406
Curator's Comment: description was created based on several sources, including, http://ec.europa.eu/health/documents/community-register/2000/200003093430/anx_3430_en.pdf

Mefenorex or (+/-)N-(3-chloropropyl)-1-methyl-2-phenylethylamine is an N-alkylated analogue of amphetamine. The therapeutic efficacy of mefenorex as an adjunctive support in the treatment of obesity for limited periods of time, as well as its ability to be well tolerated, has been amply demonstrated. Mefenorex is considered to be racemic mixture, no available data regarding enantiospecific pharmacological activity of the compound.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Unknown 2578
Obesity 203 Sources: https://www.ncbi.nlm.nih.gov/pubmed/37853 https://www.ncbi.nlm.nih.gov/pubmed/3743406	Curative	Withdrawn	Pondinil Approved Use Adjunctive therapy to diet, in patients with obesity and a body mass index (BMI) of 30 kg/m2 or higher who have not responded to an appropriate weight-reducing regimen alone Launch Date 1970

PubMed

Title	Date	PubMed
Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.	2002 Apr	11897973
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.	2002 May	12024689
Impaired cognition and attention in adults: pharmacological management strategies.	2007 Feb	19300541

Patents

Sample Use Guides

In Vivo Use Guide

40 mg/day

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:19:58 GMT 2023` Edited by `admin` on `Fri Dec 15 17:19:58 GMT 2023`
Record UNII	K98M4N387W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEFENOREX

Official Name

English

MEFENOREX [MI]

Common Name

English

N-(3-CHLOROPROPYL)-.ALPHA.-METHYLPHENETHYLAMINE

Systematic Name

English

mefenorex [INN]

Common Name

English

PHENETHYLAMINE, N-(3-CHLOROPROPYL)-.ALPHA.-METHYL-

Systematic Name

English

Mefenorex [WHO-DD]

Common Name

English

BENZENEETHANAMINE, N-(3-CHLOROPROPYL)-.ALPHA.-METHYL

Common Name

English

Classification Tree Code System Code

WHO-ATC

A08AA09