U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C12H18ClN
Molecular Weight 211.731
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEFENOREX, (+)-

SMILES

CC(CC1=CC=CC=C1)NCCCCl

InChI

InChIKey=XXVROGAVTTXONC-UHFFFAOYSA-N
InChI=1S/C12H18ClN/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,8-10H2,1H3

HIDE SMILES / InChI

Molecular Formula C12H18ClN
Molecular Weight 211.731
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including, http://ec.europa.eu/health/documents/community-register/2000/200003093430/anx_3430_en.pdf

Mefenorex or (+/-)N-(3-chloropropyl)-1-methyl-2-phenylethylamine is an N-alkylated analogue of amphetamine. The therapeutic efficacy of mefenorex as an adjunctive support in the treatment of obesity for limited periods of time, as well as its ability to be well tolerated, has been amply demonstrated. Mefenorex is considered to be racemic mixture, no available data regarding enantiospecific pharmacological activity of the compound.

Originator

Curator's Comment: # Hoffmann-La Roche

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Pondinil

Approved Use

Adjunctive therapy to diet, in patients with obesity and a body mass index (BMI) of 30 kg/m2 or higher who have not responded to an appropriate weight-reducing regimen alone

Launch Date

1970
PubMed

PubMed

TitleDatePubMed
Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.
2002 Apr
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.
2002 May
Impaired cognition and attention in adults: pharmacological management strategies.
2007 Feb
Patents

Sample Use Guides

In Vivo Use Guide
40 mg/day
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:30:27 GMT 2023
Edited
by admin
on Sat Dec 16 10:30:27 GMT 2023
Record UNII
85052999IT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEFENOREX, (+)-
Common Name English
(+)-MEFENOREX
Common Name English
BENZENEETHANAMINE, N-(3-CHLOROPROPYL)-.ALPHA.-METHYL-, (+)-
Systematic Name English
Code System Code Type Description
PUBCHEM
21777
Created by admin on Sat Dec 16 10:30:27 GMT 2023 , Edited by admin on Sat Dec 16 10:30:27 GMT 2023
PRIMARY
CAS
111051-41-3
Created by admin on Sat Dec 16 10:30:27 GMT 2023 , Edited by admin on Sat Dec 16 10:30:27 GMT 2023
PRIMARY
FDA UNII
85052999IT
Created by admin on Sat Dec 16 10:30:27 GMT 2023 , Edited by admin on Sat Dec 16 10:30:27 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
ENANTIOMER -> ENANTIOMER