LEVOMOPROLOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H21NO3
Molecular Weight	239.3107
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=CC=C1OC[C@@H](O)CNC(C)C

InChI

InChIKey=LFTFGCDECFPSQD-NSHDSACASA-N

InChI=1S/C13H21NO3/c1-10(2)14-8-11(15)9-17-13-7-5-4-6-12(13)16-3/h4-7,10-11,14-15H,8-9H2,1-3H3/t11-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C13H21NO3
Molecular Weight	239.3107
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7843592 | https://www.ncbi.nlm.nih.gov/pubmed/2570555 | Grant, W.M., Schuman, J.S. (1993) TOXICOLOGY OF THE EYE, page 234, retrieved from: https://books.google.ru/books?id=mDLYCQAAQBAJ

Levomoprolol (L-moprolol) is a beta-adrenergic blocker which was introduced as an oral medication for treatment of systemic hypertension. It was found to be effective in 2% eyedrops in reducing the intraocular pressure in glaucoma. Observations on glaucoma patients treated with the eyedrop for 1.5 to 2.5 years was without undesirable side effects. L-moprolol and dipivefrin had an equivalent effect in lowering the intraocular pressure. The association of the two drugs caused a further reduction of intraocular pressure.

Approval Year

PubMed

Title	Date	PubMed
Antihypertensive activity of (-) moprolol in man: double-blind comparison of enantiomers.	1980 Jul-Aug	6156344
Tolerability of high doses of (-)-moprolol in healthy volunteers.	1982	6125397
The pharmacokinetics of dl- and l-moprolol in the human.	1982 Feb	6120901
[The beta-blocker levomoprolol in the treatment of glaucoma].	1985	2861871
Determination by coupled high-performance liquid chromatography-gas chromatography of the beta-blocker levomoprolol in plasma following ophthalmic administration.	1989 Jul 7	2570078
Electrophysiological evaluation of the beta-blocking properties and direct membrane effects of l-moprolol and its enantiomer d-moprolol.	1989 May-Jun	2570555
Identification and determination of the enantiomers of moprolol and their metabolites in human urine by high-performance liquid chromatography and gas chromatography-mass spectrometry.	1993 Dec 22	7908669
The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension.	1994 Nov	7843592
A new catalyst for the asymmetric Henry reaction: synthesis of β-nitroethanols in high enantiomeric excess.	2012 Dec 21	23194499
Chemoenzymatic Route for the Synthesis of (S)-Moprolol, a Potential β-Blocker.	2016 Apr	26821612

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:56:17 GMT 2023` Edited by `admin` on `Sat Dec 16 17:56:17 GMT 2023`
Record UNII	K4NON6FSON
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEVOMOPROLOL

Official Name

English

MOPROLOL, (S)-

Common Name

English

(-)-(S)-1-(ISOPROPYLAMINO)-3-(O-METHOXYPHENOXY)-2-PROPANOL

Common Name

English

levomoprolol [INN]

Common Name

English

MOPROLOL L-FORM

Common Name

English

MOPROLOL, (-)-

Common Name

English

MOPROLOL L-FORM [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576