SEMBRAGILINE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H19FN2O3
Molecular Weight	342.3642
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)N[C@@H]1CN(C(=O)C1)C2=CC=C(OCC3=CC=CC(F)=C3)C=C2

InChI

InChIKey=VMAVCCUQTALHOB-INIZCTEOSA-N

InChI=1S/C19H19FN2O3/c1-13(23)21-16-10-19(24)22(11-16)17-5-7-18(8-6-17)25-12-14-3-2-4-15(20)9-14/h2-9,16H,10-12H2,1H3,(H,21,23)/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H19FN2O3
Molecular Weight	342.3642
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT01677754 | https://www.ncbi.nlm.nih.gov/pubmed/28642233 | https://www.ncbi.nlm.nih.gov/pubmed/28550255 | https://adisinsight.springer.com/drugs/800026046

Sembragiline is a potent, selective, long-acting, and reversible monoamine oxidase B (MAO-B) inhibitor developed as a potential treatment for Alzheimer's disease (AD). Sembragiline was involved in phase II clinical trial to evaluate its the safety, tolerability, and efficacy in patients with moderate AD. In addition, the drug was studied for smoking cessation, however, it failed to demonstrate efficacy during a phase II proof-of-concept trial.

Approval Year

PubMed

Title	Date	PubMed
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease.	2017-09	28642233
Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer's disease and elderly controls after oral administration of sembragiline.	2017-03	27633250
Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD).	2017	28550255

Patents

Sample Use Guides

In Vivo Use Guide

Participants will receive placebo for RO4602522 orally once daily for 12 months.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:07:03 GMT 2025` Edited by `admin` on `Mon Mar 31 19:07:03 GMT 2025`
Record UNII	K3W9672PNJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SEMBRAGILINE

Official Name

English

sembragiline [INN]

Preferred Name

English

Sembragiline [WHO-DD]

Common Name

English

SEMBRAGILINE [USAN]

Common Name

English

RG1577

Code

English

RG-1577

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C667