DAZOPRIDE FUMARATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H23ClN4O2.C4H4O4
Molecular Weight	442.894
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.CCN1CC(CN1CC)NC(=O)C2=C(OC)C=C(N)C(Cl)=C2

InChI

InChIKey=IGGKTAIAQUIFKQ-WLHGVMLRSA-N

InChI=1S/C15H23ClN4O2.C4H4O4/c1-4-19-8-10(9-20(19)5-2)18-15(21)11-6-12(16)13(17)7-14(11)22-3;5-3(6)1-2-4(7)8/h6-7,10H,4-5,8-9,17H2,1-3H3,(H,18,21);1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula	C15H23ClN4O2
Molecular Weight	326.822
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2043916 | https://www.ncbi.nlm.nih.gov/pubmed/8453682

Dazopride is an antagonist of the 5-HT3 receptor and agonist of the 5-HT4 receptor, structurally related to metoclopramide. Dazopride was developed by A. H. Robins Company as an antiemetic and gastroprokinetic drug. Dazoptide demonstrated an antiemetic effect in the clinic after i.v. infusion to patients, receiving anticancer therapy.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

i.v. infusions every 2 h beginning 30 min before the chemotherapy at doses 0.5 to 4.0 mg/kg.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:26:52 GMT 2023` Edited by `admin` on `Fri Dec 15 15:26:52 GMT 2023`
Record UNII	J8ZC30U6CH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DAZOPRIDE FUMARATE

Official Name

English

AHR-5531C

Code

English

4-Amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-O-anisamide fumarate (1:1)

Common Name

English

DAZOPRIDE FUMARATE [USAN]

Common Name

English

BENZAMIDE, 4-AMINO-5-CHLORO-N-(1,2-DIETHYL-4-PYRAZOLIDINYL)-2-METHOXY-, (E)-2-BUTENEDIOATE (1:1)

Systematic Name

English

Dazopride fumarate [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C267