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Details

Stereochemistry ACHIRAL
Molecular Formula C15H23ClN4O2
Molecular Weight 326.822
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAZOPRIDE

SMILES

CCN1CC(CN1CC)NC(=O)C2=C(OC)C=C(N)C(Cl)=C2

InChI

InChIKey=YFXIKEZOBJFVAQ-UHFFFAOYSA-N
InChI=1S/C15H23ClN4O2/c1-4-19-8-10(9-20(19)5-2)18-15(21)11-6-12(16)13(17)7-14(11)22-3/h6-7,10H,4-5,8-9,17H2,1-3H3,(H,18,21)

HIDE SMILES / InChI

Molecular Formula C15H23ClN4O2
Molecular Weight 326.822
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dazopride is an antagonist of the 5-HT3 receptor and agonist of the 5-HT4 receptor, structurally related to metoclopramide. Dazopride was developed by A. H. Robins Company as an antiemetic and gastroprokinetic drug. Dazoptide demonstrated an antiemetic effect in the clinic after i.v. infusion to patients, receiving anticancer therapy.

Approval Year

Sample Use Guides

In Vivo Use Guide
i.v. infusions every 2 h beginning 30 min before the chemotherapy at doses 0.5 to 4.0 mg/kg.
Route of Administration: Intravenous
Substance Class Chemical
Record UNII
CV07VSP2G8
Record Status Validated (UNII)
Record Version