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Details

Stereochemistry ACHIRAL
Molecular Formula C16H22FNO
Molecular Weight 263.351
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MELPERONE

SMILES

CC1CCN(CCCC(=O)c2ccc(cc2)F)CC1

InChI

InChIKey=DKMFBWQBDIGMHM-UHFFFAOYSA-N
InChI=1S/C16H22FNO/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14/h4-7,13H,2-3,8-12H2,1H3

HIDE SMILES / InChI

Molecular Formula C16H22FNO
Molecular Weight 263.351
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Melperone is an antipsychotic drug which is used in Europe for the treatment of sleep disorders, agitation and confusion states. The exact mechanism of melperone action is unknown.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
MELPERON

Approved Use

Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.
Primary
MELPERON

Approved Use

Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.
Primary
MELPERON

Approved Use

Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.
PubMed

PubMed

TitleDatePubMed
Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents.
1989 Jun
New and old antipsychotics versus clozapine in a monkey model: adverse effects and antiamphetamine effects.
1999 Jun
Melperone in the treatment of neuroleptic-resistant schizophrenia.
2001 Dec 31
Clinical management of agitation in the elderly with tiapride.
2001 Jan
[Pharmacotherapeutical approaches to insomnia patients with cardiac diseases and after heart transplantation].
2001 Oct
Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.
2001 Oct
Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.
2002 Nov 29
Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.
2003 Jan
The effect of melperone, an atypical antipsychotic drug, on cognitive function in schizophrenia.
2003 Jan 1
A comparison of two doses of melperone, an atypical antipsychotic drug, in the treatment of schizophrenia.
2003 Jul 1
Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.
2003 Mar
P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.
2004 Dec
[The case of a 86-years old woman first diagnosed with Huntington's disease].
2004 Nov
Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor.
2005 Feb
Antipsychotic drugs and QT prolongation.
2005 Sep
Cytochrome P450 2D6 dependent metabolization of risperidone is inhibited by melperone.
2006 Apr
Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series.
2006 Feb 28
Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
2006 Mar 30
The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).
2008 Dec 22
[Recurrent dysregulation of body temperature during antipsychotic pharmacotherapy].
2008 Mar
Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism.
2009 Apr
Antipsychotics and risk of venous thromboembolism: A population-based case-control study.
2009 Aug 9
Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics.
2009 Jul
The ABCB1 transporter gene and antidepressant response.
2009 Mar 24
Changes in weight and body mass index during treatment with melperone, clozapine and typical neuroleptics.
2010 Apr 30
Acute administration of clozapine and risperidone altered dopamine metabolism more in rat caudate than in nucleus accumbens: a dose-response relationship.
2010 Apr-Jun
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs and pimavanserin (ACP 103), a 5-hydroxytryptamine(2A) receptor inverse agonist.
2010 Feb
The effect of metformin on anthropometrics and insulin resistance in patients receiving atypical antipsychotic agents: a meta-analysis.
2010 Oct
Four-digit replantation in a mentally retarded person: a case report.
2010 Sep 30
Patents

Sample Use Guides

The recommended dose of melperone (in form of hydrochloride salt) is 25-75 mg/day. In the case of restless and confused patients the drug is given at a dose of 50-100 mg at the beginning of the treatment. The dose can be increased up to 200 mg if necessary. In severe disorders of confusion and confusion with aggression and hallucinatory conditions, the daily dose can be increased to up to 400 mg melperone HCl.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 14:13:51 UTC 2021
Edited
by admin
on Sat Jun 26 14:13:51 UTC 2021
Record UNII
J8WA3K39B7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MELPERONE
INN   MI   WHO-DD  
INN  
Official Name English
METYLPERON
Common Name English
MELPERONE [MI]
Common Name English
MELPERONE [INN]
Common Name English
BUNIL
Brand Name English
FG 5111
Code English
FG-5111
Code English
MELPERONE [WHO-DD]
Common Name English
4'-FLUORO-4-(4-METHYLPIPERIDINO)BUTYROPHENONE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
WHO-ATC N05AD03
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
WHO-VATC QN05AD03
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
Code System Code Type Description
ChEMBL
CHEMBL1531134
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
CAS
3575-80-2
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
MESH
C008522
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
RXCUI
29961
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY RxNorm
WIKIPEDIA
MELPERONE
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
MERCK INDEX
M7165
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY Merck Index
PUBCHEM
15387
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
DRUG BANK
DB09224
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
EPA CompTox
3575-80-2
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
DRUG CENTRAL
1677
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
EVMPD
SUB08727MIG
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
NCI_THESAURUS
C73293
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
FDA UNII
J8WA3K39B7
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
INN
2070
Created by admin on Sat Jun 26 14:13:52 UTC 2021 , Edited by admin on Sat Jun 26 14:13:52 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SHORT-ACTING
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY