MELPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H22FNO
Molecular Weight	263.3504
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

InChI

InChIKey=DKMFBWQBDIGMHM-UHFFFAOYSA-N

InChI=1S/C16H22FNO/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14/h4-7,13H,2-3,8-12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H22FNO
Molecular Weight	263.3504
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad

Melperone is an antipsychotic drug which is used in Europe for the treatment of sleep disorders, agitation and confusion states. The exact mechanism of melperone action is unknown.

CNS Activity

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Sleep disorder 20 Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad	Primary	Approved 8429	MELPERON Approved Use Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.
Confusional state 2 Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad	Primary	Approved 8429	MELPERON Approved Use Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.
Psychomotor agitation 6 Sources: http://www.ratiopharm.de/index.php?eID=dumpFile&t=f&f=60721&g=-1&r=1894%2C1894&token=c00130080812868362409a3ab52b4a122b2af3ad	Primary	Approved 8429	MELPERON Approved Use Melperon is used to treat sleep disorders, confusion states, and to suppress psychomotor restlessness and excitement, especially in geriatric and psychiatric patients.

PubMed

Title	Date	PubMed
Melperone in the treatment of neuroleptic-resistant schizophrenia.	2001 Dec 31	11814539
Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.	2002 Nov 29	12445705
Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.	2003 Jan	12649767
Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.	2003 Mar	12644990
Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics.	2009 Jul	19551763

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose of melperone (in form of hydrochloride salt) is 25-75 mg/day. In the case of restless and confused patients the drug is given at a dose of 50-100 mg at the beginning of the treatment. The dose can be increased up to 200 mg if necessary. In severe disorders of confusion and confusion with aggression and hallucinatory conditions, the daily dose can be increased to up to 400 mg melperone HCl.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:55:16 GMT 2023` Edited by `admin` on `Fri Dec 15 15:55:16 GMT 2023`
Record UNII	J8WA3K39B7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MELPERONE

Official Name

English

METYLPERON

Common Name

English

MELPERONE [MI]

Common Name

English

Melperone [WHO-DD]

Common Name

English

melperone [INN]

Common Name

English

BUNIL

Brand Name

English

FG 5111

Code

English

FG-5111

Code

English

4'-FLUORO-4-(4-METHYLPIPERIDINO)BUTYROPHENONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710