NORLEVORPHANOL

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H21NO
Molecular Weight	243.344
Optical Activity	( - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OC1=CC2=C(C[C@H]3NCC[C@@]24CCCC[C@@H]34)C=C1

InChI

InChIKey=IYNWSQDZXMGGGI-NUEKZKHPSA-N

InChI=1S/C16H21NO/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12/h4-5,10,13,15,17-18H,1-3,6-9H2/t13-,15+,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H21NO
Molecular Weight	243.344
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Norlevorphanol is the levo-isomer of 3-hydroxymorphinan (morphinan-3-ol). It is is an opioid analgesic of the morphinan family. Norlevorphanol is a Schedule I controlled substance (opiate).

Approval Year

PubMed

Show entries

Title	Date	PubMed
Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel.	2003 Jan-Feb	12892522
Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.	2004 Dec 1	15498516
LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation.	2004 Dec 25	15556536
3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity.	2005 Mar	15596482
Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers.	2006 Jul	16621933

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Patents

Substance Class	Chemical
Record UNII	IL94262N7K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IDS-NN-006

Preferred Name

English

NORLEVORPHANOL

Official Name

English

2H-10,4A-IMINOETHANOPHENANTHREN-6-OL, 1,3,4,9,10,10A-HEXAHYDRO-

Systematic Name

English

norlevorphanol [INN]

Common Name

English

(-)-3-HYDROXYMORPHINAN

Systematic Name

English

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Classification Tree

Code System

Code

Sec. 1308.11 Schedule I.

DEA NO.

9634

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Code System

Code

Type

Description

EVMPD

SUB09375MIG

PRIMARY

SMS_ID

100000083600

PRIMARY

INN

873

PRIMARY

WIKIPEDIA

NORLEVORPHANOL

PRIMARY

Norlevorphanol is an opioid analgesic of the morphinan class. It was never marketed.

MESH

C054116

PRIMARY

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Related Record

Type

Details


					R1M65348NR

NORLEVORPHANOL HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:

RELATIONSHIP_AMOUNT 87 (average)


					V44B57LQ23

NORLEVORPHANOL HYDROBROMIDE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:

RELATIONSHIP_AMOUNT 75 (average)

Showing 1 to 2 of 2 entries

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Show entries

Related Record

Type

Details


					IL94262N7K

NORLEVORPHANOL

ACTIVE MOIETY

Amount:

Showing 1 to 1 of 1 entries

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