Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H21NO.ClH |
| Molecular Weight | 279.805 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.OC1=CC=C2C[C@H]3NCC[C@@]4(CCCC[C@@H]34)C2=C1
InChI
InChIKey=TVWLCOZEOOAJBT-QALYCTJVSA-N
InChI=1S/C16H21NO.ClH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C16H21NO |
| Molecular Weight | 243.344 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition. | 2002 Aug 22 |
|
| Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel. | 2003 Jan-Feb |
|
| Determination of dextromethorphan and its metabolites in rat serum by liquid-liquid extraction and liquid chromatography with fluorescence detection. | 2003 May 25 |
|
| Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism. | 2004 Dec 1 |
|
| Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers. | 2005 Jun |
|
| Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers. | 2006 Jul |
|
| Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. | 2008 Jan |
|
| Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism. | 2009 Feb |
|
| Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. | 2011 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:01:19 GMT 2025
by
admin
on
Mon Mar 31 18:01:19 GMT 2025
|
| Record UNII |
R1M65348NR
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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Common Name | English | ||
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Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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53448-65-0
Created by
admin on Mon Mar 31 18:01:19 GMT 2025 , Edited by admin on Mon Mar 31 18:01:19 GMT 2025
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PRIMARY | |||
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R1M65348NR
Created by
admin on Mon Mar 31 18:01:19 GMT 2025 , Edited by admin on Mon Mar 31 18:01:19 GMT 2025
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PRIMARY | |||
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11558208
Created by
admin on Mon Mar 31 18:01:19 GMT 2025 , Edited by admin on Mon Mar 31 18:01:19 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |