NORLEVORPHANOL HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H21NO.ClH
Molecular Weight	279.805
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of NORLEVORPHANOL HYDROCHLORIDE

Structure Search

SMILES

Cl.[H][C@@]12CCCC[C@@]13CCN[C@@H]2CC4=CC=C(O)C=C34

InChI

InChIKey=TVWLCOZEOOAJBT-QALYCTJVSA-N

InChI=1S/C16H21NO.ClH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m0./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H21NO
Molecular Weight	243.344
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y | https://www.drugfuture.com/chemdata/norlevorphanol.html | https://books.google.ru/books?id=4yaGePenGKgC&pg=PA469&lpg=PA469&dq=NORLEVORPHANOL retrieved from The A-Z Encyclopedia of Alcohol and Drug Abuse By Thomas Nordegren, p.469

Norlevorphanol is the levo-isomer of 3-hydroxymorphinan (morphinan-3-ol). It is is an opioid analgesic of the morphinan family. Norlevorphanol is a Schedule I controlled substance (opiate).

Approval Year

PubMed

Title	Date	PubMed
Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel.	2003 Jan-Feb	12892522
Effect of methamphetamine on the pharmacokinetics of dextromethorphan and midazolam in rats.	2005 Jul-Sep	16250257
3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro.	2006 Dec	17142799
Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection.	2007 Nov 1	17919999
Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects.	2008 Jan	18198471

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:53 GMT 2023` Edited by `admin` on `Fri Dec 15 15:33:53 GMT 2023`
Record UNII	R1M65348NR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NORLEVORPHANOL HYDROCHLORIDE

Common Name

English

MORPHINAN-3-OL, HYDROCHLORIDE, (14.ALPHA.)-(±)-

Systematic Name

English

Code System Code Type Description

CAS

53448-65-0

Created by admin on Fri Dec 15 15:33:53 GMT 2023 , Edited by admin on Fri Dec 15 15:33:53 GMT 2023

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FDA UNII

R1M65348NR

Created by admin on Fri Dec 15 15:33:53 GMT 2023 , Edited by admin on Fri Dec 15 15:33:53 GMT 2023

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PUBCHEM

11558208

Created by admin on Fri Dec 15 15:33:53 GMT 2023 , Edited by admin on Fri Dec 15 15:33:53 GMT 2023

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