U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Dusquetide (also referred to by its research name SGX94) is a fully synthetic, 5-amino acid peptide with high aqueous solubility and stability. Preclinical data indicate that dusquetide is active in models of a wide range of therapeutic indications including severe side-effects of chemo- and/or radiation-therapy and life-threatening bacterial infections. Dusquetide, a novel Innate Defense Regulator, has demonstrated both nonclinical and clinical efficacy in ameliorating severe oral mucositis (SOM). Long term follow-up studies from the Phase 2 clinical study evaluating dusquetide as a treatment for SOM in head and neck cancer (HNC) patients receiving CRT have now been completed. Extended analysis indicates that dusquetide therapy was well-tolerated and did not contribute to increased infection, tumor growth or mortality. Potential ancillary benefits of duquetide therapy were also identified. A multi-center, double-blind, placebo-controlled, pivital Phase 3 clinical study in oral mucositis in head and neck cancer patients has been initiated.

Approval Year

PubMed

PubMed

TitleDatePubMed
Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study.
2016 Dec 10
Dusquetide: Reduction in oral mucositis associated with enduring ancillary benefits in tumor resolution and decreased mortality in head and neck cancer patients.
2017 Sep

Sample Use Guides

1.5, 3.0, and 6.0 mg/kg administered over 4 minutes
Route of Administration: Intravenous
Substance Class Protein
Created
by admin
on Thu Jul 06 14:40:58 UTC 2023
Edited
by admin
on Thu Jul 06 14:40:58 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
IKX7W49NLN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DUSQUETIDE
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
SGX-942
Code English
SGX-94
Code English
L-ARGINYL-L-ISOLEUCYL-L-VALYL-L-PROLYL-L-ALANINAMIDE
Systematic Name English
SGX94
Code English
IMX-942
Code English
Dusquetide [WHO-DD]
Common Name English
ARG-ILE-VAL-PRO-ALA-NH2
Common Name English
SGX942
Code English
L-ALANINAMIDE, L-ARGINYL-L-ISOLEUCYL-L-VALYL-L-PROLYL-
Systematic Name English
DUSQUETIDE [USAN]
Common Name English
dusquetide [INN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 395913
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
FDA ORPHAN DRUG 528016
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
Code System Code Type Description
PUBCHEM
71722017
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
NCI_THESAURUS
C113437
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
INN
10108
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
USAN
BC-47
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
CAS
931395-42-5
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
FDA UNII
IKX7W49NLN
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
ChEMBL
CHEMBL3545314
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
DRUG BANK
DB11879
Created by admin on Thu Jul 06 14:40:58 UTC 2023 , Edited by admin on Thu Jul 06 14:40:58 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:SEQUENCE(CALCULATED) CHEMICAL