Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2Al.3O4S |
Molecular Weight | 342.151 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O
InChI
InChIKey=DIZPMCHEQGEION-UHFFFAOYSA-H
InChI=1S/2Al.3H2O4S/c;;3*1-5(2,3)4/h;;3*(H2,1,2,3,4)/q2*+3;;;/p-6
Molecular Formula | O4S |
Molecular Weight | 96.063 |
Charge | -2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Al |
Molecular Weight | 26.9815 |
Charge | 3 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.domeboro.com/about-domeboro/Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate.
The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.
Originator
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2364031 |
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Target ID: GO:0042310 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | DOMEBORO Approved UseTemporarily relieves minor skin irritations due to:
– Poison ivy | – Poison oak
– Poison sumac | – Insect bites
– Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry |
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Curative | DOMEBORO Approved UseThis medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection. |
PubMed
Title | Date | PubMed |
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The ineffectiveness of aluminum subacetate in rheumatoid arthritis. | 1948 Apr 8 |
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Cardiovascular manifestations of aluminium phosphide intoxication. | 1989 Sep |
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Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S. | 1994 Nov 25 |
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Effect of aluminum phosphide on blood glucose level. | 1999 Feb |
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Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
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Intravascular hemolysis in aluminium phosphide poisoning. | 1999 Sep |
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Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride. | 2001 Jan |
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Aluminum as a toxicant. | 2002 Aug |
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Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system. | 2002 May |
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Parenteral nutrition-associated cholestasis in neonates: the role of aluminum. | 2003 Sep |
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Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain. | 2003 Sep 15 |
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[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method]. | 2004 Nov |
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Aluminum: new recognition of an old problem. | 2005 Dec |
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Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. | 2006 |
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Aluminum and Alzheimer's disease, a personal perspective after 25 years. | 2006 |
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Some aspects of astroglial functions and aluminum implications for neurodegeneration. | 2006 Aug 30 |
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The role of aluminum and copper on neuroinflammation and Alzheimer's disease. | 2006 Nov |
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Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease. | 2006 Nov |
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Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine. | 2007 Oct |
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Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. | 2007 Oct |
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Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet. | 2007 Sep-Oct |
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Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor. | 2008 Jul |
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Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat. | 2010 Jul |
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Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome. | 2011 Mar |
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New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle. | 2013 Apr |
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Pesticide exposure and depression among male private pesticide applicators in the agricultural health study. | 2014 Sep |
Sample Use Guides
DOMEBORO® SOOTHING SOAK
– dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water
– stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use
For use as a soak:
– soak affected area for 15 to 30 minutes as needed, or as directed by a doctor
– repeat 3 times a day or as directed by a doctor
– discard solution after each use.
For use as a compress or wet dressing:
– soak a clean, soft cloth in the solution.
– apply cloth loosely to affected area for 15 to 30 minutes
– repeat as needed or as directed by a doctor
– discard solution after each use
Route of Administration:
Topical
Substance Class |
Chemical
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I7T908772F
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C2554
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ALUMINUM SULFATE ANHYDROUS
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PRIMARY | Description: Colourless, lustrous crystals or crystalline masses, or a white, crystalline powder; odourless. Solubility: Soluble in cold water; freely soluble in hot water; practically insoluble in ethanol (~750 g/l) TS. Category: Astringent drug; used in the preparation of aluminium acetate solution. Storage: Aluminium sulfate should be kept in a well-closed container.Aluminium sulfate contains a variable quantity of water of crystallization. Requirement: Aluminium sulfate contains not less than 51.0% and not more than the equivalent of 59.0% of Al2(SO4)3. | ||
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SOLVATE->ANHYDROUS | |||
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SOLVATE->ANHYDROUS | |||
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SALT/SOLVATE -> PARENT | |||
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ACTIVE MOIETY | |||
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ACTIVE MOIETY |