ALUMINUM SULFATE ANHYDROUS

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Al.3O4S
Molecular Weight	342.151
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O

InChI

InChIKey=DIZPMCHEQGEION-UHFFFAOYSA-H

InChI=1S/2Al.3H2O4S/c;;3*1-5(2,3)4/h;;3*(H2,1,2,3,4)/q2*+3;;;/p-6

HIDE SMILES / InChI

Molecular Formula	O4S
Molecular Weight	96.063
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Al
Molecular Weight	26.9815386
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 40 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 30 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1447

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 52 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8583	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 38 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8583	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
Molecular basis of carcinogenicity of tungsten alloy particles.	2015-03-15	25620057
1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt.	2014-03-25	24412238
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.	2013-11	23499988
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.	2007-10	17931164
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation.	2007-10	17931150
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.	2007-09-18	17870524
Ototoxic effect of Burow solution applied to the guinea pig middle ear.	2007-08	17450104
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.	2006-11	17119296
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.	2006-11	17119290
Aluminum and Alzheimer's disease: a new look.	2006-11	17119287
The role of aluminum and copper on neuroinflammation and Alzheimer's disease.	2006-11	17119285
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.	2006-11	17119283
Some aspects of astroglial functions and aluminum implications for neurodegeneration.	2006-08-30	16529821
Aluminum and Alzheimer's disease, a personal perspective after 25 years.	2006	17004365
Aluminum: new recognition of an old problem.	2005-12	16198633
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.	2005-11	16308486
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].	2004-11	15516810
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc.	2003-11-15	14596888
Aluminum inclusion macrophagic myofasciitis: a recently identified condition.	2003-11	14753387
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.	2003-09-15	14507471
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.	2003-09	14552065
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.	2003	12851164
Aluminum as a toxicant.	2002-08	15068131
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.	2002	12511178
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.	1999-05	10327022
The antibacterial activity of acetic acid and Burow's solution as topical otological preparations.	1998-10	10211213
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.	1948-04-08	18911341

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:18 GMT 2025`
Record UNII	I7T908772F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALUMINUM SULFATE ANHYDROUS

Common Name

English

E-520

Preferred Name

English

NSC-54563

Code

English

SULFURIC ACID ALUMINUM(3+) SALT (3:2)

Common Name

English

ALUMINUM SULFATE ANHYDROUS [II]

Common Name

English

ALUMINUM SULFATE ANHYDROUS [HSDB]

Common Name

English

ALUMINUM SESQUISULFATE

Common Name

English

ALUMINUM SULFATE [MI]

Common Name

English

ALUMINUM SULPHATE ANHYDROUS

Common Name

English

SULFATODIALUMINUM DISULFATE (AL2(SO4)3)

Systematic Name

English

ALUMINII SULFAS, ANHYDROUS [WHO-IP LATIN]

Common Name

English

INS-520

Code

English

SULFURIC ACID, ALUMINUM SALT

Common Name

English

DIALUMINUM TRISULFATE

Systematic Name

English

SULFURIC ACID, ALUMINIUM SALT

Common Name

English

Aluminium sulfate [WHO-DD]

Common Name

English

DIALUMINUM SULFATE

Systematic Name

English

INS NO.520

Code

English

ALUMINIUM SULFATE ANHYDROUS

Common Name

English

FERTOSAN

Common Name

English

ALUMINIUM SULFATE, ANHYDROUS [WHO-IP]

Common Name

English

ALUM CAKE

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-520