MAZATICOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H27NO3S2
Molecular Weight	405.574
Optical Activity	( + / - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1[C@@H]2CCC(C)(C)[C@@H]1C[C@@H](C2)OC(=O)C(O)(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=AMHPTVWBZSYFSS-HWOWSKLDSA-N

InChI=1S/C21H27NO3S2/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3/t14?,15-,16?/m1/s1

HIDE SMILES / InChI

Molecular Formula	C21H27NO3S2
Molecular Weight	405.574
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4996373
Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167, https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm

Mazaticol is an anti-acetylcholine agent used in Japan for the treatment of Parkinson's syndrome.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Parkinson's syndrome due to psychotropic drug administration 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4996373	Primary		Approved 8429	PENTONA Approved Use Parkinson's syndrome due to psychotropic drug administration

PubMed

Title	Date	PubMed
Pharmacology of a new anti-parkinsonian drug: KAO-264.	1971 Apr	4996373
[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent].	1971 Jul	5000167
Metabolic fate of 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl , -di(2-thienyl)glycolate hydrochloride monohydrate (PG-501).	1972 Aug	4639305
[Absorption, distribution and excretion of 14 C-labelled 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl a,a-di(2-thienyl)glycolate hydrochloride monohydrate (PG-501)].	1972 Aug	4674420
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients.	1982	6962040
Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.	1990 Sep	2236897
Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.	2002	11888334

Sample Use Guides

In Vivo Use Guide

1 tablet (4 mg) is administered orally three times a day. In case of taking Pentona 1%, 0.4 g should be administered the same way.

Route of Administration: Oral

In Vitro Use Guide

Anti-acetylcholine activity of mazaticol on he isolated guinea-pig ileum preparation was studied in vitro. ED50 value was 6.4*10(-9) g/ml.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:31 UTC 2023` Edited by `admin` on `Fri Dec 15 16:12:31 UTC 2023`
Record UNII	I6X824OGWZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAZATICOL

Official Name

English

(±)-2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, -(1R*,3R*,5R*)-6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER

Common Name

English

Mazaticol [WHO-DD]

Common Name

English

6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3.BETA.-YL DI-2-THIENYLGLYCOLATE

Common Name

English

mazaticol [INN]

Common Name

English

2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, (1R,3R,5R)-6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER, REL-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880