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Details

Stereochemistry RACEMIC
Molecular Formula C21H27NO3S2
Molecular Weight 405.574
Optical Activity ( + / - )
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAZATICOL

SMILES

CN1[C@@H]2CCC(C)(C)[C@@H]1C[C@@H](C2)OC(=O)C(O)(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=AMHPTVWBZSYFSS-HWOWSKLDSA-N
InChI=1S/C21H27NO3S2/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3/t14?,15-,16?/m1/s1

HIDE SMILES / InChI
Molecular Formula C21H27NO3S2
Molecular Weight 405.574
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167, https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm

Mazaticol is an anti-acetylcholine agent used in Japan for the treatment of Parkinson's syndrome.

CNS Activity

Originator

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
PENTONA

Approved Use

Parkinson's syndrome due to psychotropic drug administration
Doses

Doses

DosePopulationAdverse events​
8 mg single, oral
Studied dose
Dose: 8 mg
Route: oral
Route: single
Dose: 8 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/1589555/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/1589555/
Other AEs: uditory hallucination, Delirium...
Other AEs:
uditory hallucination (83.3%)
Delirium
Sources:
https://pubmed.ncbi.nlm.nih.gov/1589555/
AEs

AEs

AESignificanceDosePopulation
Delirium
8 mg single, oral
Studied dose
Dose: 8 mg
Route: oral
Route: single
Dose: 8 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/1589555/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/1589555/
uditory hallucination 83.3%
8 mg single, oral
Studied dose
Dose: 8 mg
Route: oral
Route: single
Dose: 8 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/1589555/
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/1589555/
PubMed

PubMed

TitleDatePubMed
Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.
2002
Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.
1990-09
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients.
1982
Metabolic fate of 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl , -di(2-thienyl)glycolate hydrochloride monohydrate (PG-501).
1972-08
[Absorption, distribution and excretion of 14 C-labelled 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl a,a-di(2-thienyl)glycolate hydrochloride monohydrate (PG-501)].
1972-08
[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent].
1971-07
Pharmacology of a new anti-parkinsonian drug: KAO-264.
1971-04

Sample Use Guides

In Vivo Use Guide
1 tablet (4 mg) is administered orally three times a day. In case of taking Pentona 1%, 0.4 g should be administered the same way.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: the full-text can be found here: https://www.jstage.jst.go.jp/article/fpj1944/67/4/67_4_387/_pdf
Anti-acetylcholine activity of mazaticol on he isolated guinea-pig ileum preparation was studied in vitro. ED50 value was 6.4*10(-9) g/ml.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:21:52 GMT 2025
Edited
by admin
on Mon Mar 31 18:21:52 GMT 2025
Record UNII
I6X824OGWZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
(±)-2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, -(1R*,3R*,5R*)-6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER
Preferred Name English
MAZATICOL
INN   WHO-DD  
INN  
Official Name English
Mazaticol [WHO-DD]
Common Name English
6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3.BETA.-YL DI-2-THIENYLGLYCOLATE
Common Name English
mazaticol [INN]
Common Name English
2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, (1R,3R,5R)-6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER, REL-
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66880
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
WHO-ATC N04AA10
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
WHO-VATC QN04AA10
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
Code System Code Type Description
CAS
42024-98-6
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
PRIMARY
EPA CompTox
DTXSID1057743
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
PRIMARY
FDA UNII
I6X824OGWZ
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
PRIMARY
DRUG BANK
DB13448
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
PRIMARY
EVMPD
SUB08655MIG
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
PRIMARY
DRUG CENTRAL
1639
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
PRIMARY
SMS_ID
100000081727
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
PRIMARY
MESH
C003706
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
PRIMARY
PUBCHEM
10431413
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
PRIMARY
WIKIPEDIA
MAZATICOL
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
PRIMARY
NCI_THESAURUS
C82233
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
PRIMARY
INN
3410
Created by admin on Mon Mar 31 18:21:52 GMT 2025 , Edited by admin on Mon Mar 31 18:21:52 GMT 2025
PRIMARY
ChEMBL
CHEMBL2105187
Created by admin on Mon Mar 31 18:21:53 GMT 2025 , Edited by admin on Mon Mar 31 18:21:53 GMT 2025
PRIMARY
Related Record Type Details
Structure of MAZATICOL HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of MAZATICOL
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