MAZATICOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H27NO3S2.ClH
Molecular Weight	442.035
Optical Activity	( + / - )
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN1C2CCC(C)(C)C1CC(C2)OC(=O)C(O)(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=KOYYWMFYAIFCBI-UHFFFAOYSA-N

InChI=1S/C21H27NO3S2.ClH/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18;/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H27NO3S2
Molecular Weight	405.574
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4996373
Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167, https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm

Mazaticol is an anti-acetylcholine agent used in Japan for the treatment of Parkinson's syndrome.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Parkinson's syndrome due to psychotropic drug administration 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4996373	Primary		Approved 8429	PENTONA Approved Use Parkinson's syndrome due to psychotropic drug administration

PubMed

Title	Date	PubMed
Pharmacology of a new anti-parkinsonian drug: KAO-264.	1971 Apr	4996373
[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent].	1971 Jul	5000167
Metabolic fate of 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl , -di(2-thienyl)glycolate hydrochloride monohydrate (PG-501).	1972 Aug	4639305
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients.	1982	6962040
Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.	1990 Sep	2236897
Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.	2002	11888334

Sample Use Guides

In Vivo Use Guide

1 tablet (4 mg) is administered orally three times a day. In case of taking Pentona 1%, 0.4 g should be administered the same way.

Route of Administration: Oral

In Vitro Use Guide

Anti-acetylcholine activity of mazaticol on he isolated guinea-pig ileum preparation was studied in vitro. ED50 value was 6.4*10(-9) g/ml.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:16:40 GMT 2023` Edited by `admin` on `Fri Dec 15 20:16:40 GMT 2023`
Record UNII	44WQI5180Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MAZATICOL HYDROCHLORIDE

Common Name

English

MAZATICOL HYDROCHLORIDE [JAN]

Common Name

English

PG 501

Code

English

KAO 264

Code

English

Mazaticol hydrochloride [WHO-DD]

Common Name

English

PG-501

Code

English

2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, (1R,3R,5R)-6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER, HYDROCHLORIDE, REL-

Common Name

English

KAO-264

Code

English

PENTONA

Brand Name

English

Code System Code Type Description

FDA UNII

44WQI5180Q