MAZATICOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H27NO3S2.ClH
Molecular Weight	442.035
Optical Activity	( + / - )
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN1C2CCC(C)(C)C1CC(C2)OC(=O)C(O)(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=KOYYWMFYAIFCBI-UHFFFAOYSA-N

InChI=1S/C21H27NO3S2.ClH/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18;/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H27NO3S2
Molecular Weight	405.574
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4996373
Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167, https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm

Mazaticol is an anti-acetylcholine agent used in Japan for the treatment of Parkinson's syndrome.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Parkinson's syndrome due to psychotropic drug administration 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4996373	Primary		Approved 8583	PENTONA Approved Use Parkinson's syndrome due to psychotropic drug administration

Doses

Dose	Population	Adverse events
8 mg single, oral Studied dose Dose: 8 mg Route: oral Route: single Dose: 8 mg Sources: https://pubmed.ncbi.nlm.nih.gov/1589555/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/1589555/	Other AEs: uditory hallucination, Delirium... Other AEs: uditory hallucination (83.3%) Delirium Sources: https://pubmed.ncbi.nlm.nih.gov/1589555/

AEs

AE	Significance	Dose	Population
Delirium		8 mg single, oral Studied dose Dose: 8 mg Route: oral Route: single Dose: 8 mg Sources: https://pubmed.ncbi.nlm.nih.gov/1589555/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/1589555/
uditory hallucination	83.3%	8 mg single, oral Studied dose Dose: 8 mg Route: oral Route: single Dose: 8 mg Sources: https://pubmed.ncbi.nlm.nih.gov/1589555/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/1589555/

PubMed

Title	Date	PubMed
Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.	2002	11888334
Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.	1990-09	2236897
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients.	1982	6962040
Metabolic fate of 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl , -di(2-thienyl)glycolate hydrochloride monohydrate (PG-501).	1972-08	4639305
[Absorption, distribution and excretion of 14 C-labelled 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl a,a-di(2-thienyl)glycolate hydrochloride monohydrate (PG-501)].	1972-08	4674420
[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent].	1971-07	5000167
Pharmacology of a new anti-parkinsonian drug: KAO-264.	1971-04	4996373

Sample Use Guides

In Vivo Use Guide

1 tablet (4 mg) is administered orally three times a day. In case of taking Pentona 1%, 0.4 g should be administered the same way.

Route of Administration: Oral

In Vitro Use Guide

Anti-acetylcholine activity of mazaticol on he isolated guinea-pig ileum preparation was studied in vitro. ED50 value was 6.4*10(-9) g/ml.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:06:12 GMT 2025` Edited by `admin` on `Mon Mar 31 20:06:12 GMT 2025`
Record UNII	44WQI5180Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAZATICOL HYDROCHLORIDE

Common Name

English

PENTONA

Preferred Name

English

MAZATICOL HYDROCHLORIDE [JAN]

Common Name

English

PG 501

Code

English

KAO 264

Code

English

Mazaticol hydrochloride [WHO-DD]

Common Name

English

PG-501

Code

English

2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, (1R,3R,5R)-6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER, HYDROCHLORIDE, REL-

Common Name

English

KAO-264

Code

English

Code System Code Type Description

FDA UNII

44WQI5180Q