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Details

Stereochemistry RACEMIC
Molecular Formula C21H27NO3S2.ClH.H2O
Molecular Weight 460.05
Optical Activity ( + / - )
Defined Stereocenters 0 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAZATICOL HYDROCHLORIDE MONOHYDRATE

SMILES

O.Cl.CN1C2CCC(C)(C)C1CC(C2)OC(=O)C(O)(C3=CC=CS3)C4=CC=CS4

InChI

InChIKey=ISDSJXYEVLNWPV-UHFFFAOYSA-N
InChI=1S/C21H27NO3S2.ClH.H2O/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18;;/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3;1H;1H2

HIDE SMILES / InChI
Molecular Formula C21H27NO3S2
Molecular Weight 405.574
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167, https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm

Mazaticol is an anti-acetylcholine agent used in Japan for the treatment of Parkinson's syndrome.

CNS Activity

Originator

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
PENTONA

Approved Use

Parkinson's syndrome due to psychotropic drug administration
PubMed

PubMed

TitleDatePubMed
Metabolic fate of 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl , -di(2-thienyl)glycolate hydrochloride monohydrate (PG-501).
1972 Aug
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients.
1982

Sample Use Guides

In Vivo Use Guide
1 tablet (4 mg) is administered orally three times a day. In case of taking Pentona 1%, 0.4 g should be administered the same way.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: the full-text can be found here: https://www.jstage.jst.go.jp/article/fpj1944/67/4/67_4_387/_pdf
Anti-acetylcholine activity of mazaticol on he isolated guinea-pig ileum preparation was studied in vitro. ED50 value was 6.4*10(-9) g/ml.
Substance Class Chemical
Created
by admin
on Sat Dec 16 04:51:35 GMT 2023
Edited
by admin
on Sat Dec 16 04:51:35 GMT 2023
Record UNII
T64234598Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MAZATICOL HYDROCHLORIDE MONOHYDRATE
Common Name English
2-THIOPHENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-2-THIENYL-, 6,6,9-TRIMETHYL-9-AZABICYCLO(3.3.1)NON-3-YL ESTER, HYDROCHLORIDE, MONOHYDRATE, EXO-
Common Name English
MAZATICOL HYDROCHLORIDE HYDRATE [JAN]
Common Name English
MAZATICOL HYDROCHLORIDE HYDRATE
JAN  
Common Name English
Code System Code Type Description
PUBCHEM
11954326
Created by admin on Sat Dec 16 04:51:35 GMT 2023 , Edited by admin on Sat Dec 16 04:51:35 GMT 2023
PRIMARY
CAS
65104-02-1
Created by admin on Sat Dec 16 04:51:35 GMT 2023 , Edited by admin on Sat Dec 16 04:51:35 GMT 2023
PRIMARY
FDA UNII
T64234598Y
Created by admin on Sat Dec 16 04:51:35 GMT 2023 , Edited by admin on Sat Dec 16 04:51:35 GMT 2023
PRIMARY
Related Record Type Details
Structure of MAZATICOL HYDROCHLORIDE
ANHYDROUS->SOLVATE
NIH
NCATS
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