Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H32O |
Molecular Weight | 300.4782 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 6 / 6 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@@](O)(CC=C)[C@@]1(C)CC[C@]3([H])[C@@]4([H])CCCC=C4CC[C@@]23[H]
InChI
InChIKey=ATXHVCQZZJYMCF-XUDSTZEESA-N
InChI=1S/C21H32O/c1-3-12-21(22)14-11-19-18-9-8-15-6-4-5-7-16(15)17(18)10-13-20(19,21)2/h3,6,16-19,22H,1,4-5,7-14H2,2H3/t16-,17+,18+,19-,20-,21-/m0/s1
Molecular Formula | C21H32O |
Molecular Weight | 300.4782 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 6 / 6 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.drugbank.ca/drugs/DB01431
Sources: https://www.drugbank.ca/drugs/DB01431
Allylestrenol (INN) (brand names Gestanon, Gestanin, Orageston, Turinal, Gestin, others), or allyloestrenol (BAN), also known as 17α-allylestr-4-en-17β-ol or as 3-deketo-17α-allyl-19-nortestosterone, is a synthetic steroid with progestational activity, that is used to prevent threatened miscarriage, recurrent pregnancy loss, and premature labor. Allylestrenol has also been studied as a treatment for benign prostatic hyperplasia in men, with encouraging results. Although it is less potent as a progestogen relative to many other 19-nortestosterone derivatives, allylestrenol is said to be virtually devoid of androgenic, estrogenic, or glucocorticoid activity, and hence, unlike virtually all other 19-nortestosterone derivatives, appears to be a pure progestogen with similar effects to those of progesterone. Allylestrenol is widely marketed throughout Europe, including Russia and many other European countries, and is also available in Japan, Hong Kong, India, Bangladesh, Indonesia, and much of Southeast Asia, though notably not in the United States or Canada.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL208 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27121188 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Allynol Approved UseUnknown |
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Preventing | Allynol Approved UseUnknown |
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Preventing | Allynol Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Effect of tamoxifen treatment at adolescent age on the sexual behaviour and steroid hormone receptor binding of adult female rats. | 2001 |
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Similarities and dissimilarities of newborn and adolescent rats in the binding capacity of thymic glucocorticoid receptors. | 2001 Mar |
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[Clinical effects of allylestrenol on patients with benign prostatic hyperplasia (BPH) evaluated with criteria for treatment efficacy in BPH]. | 2002 May |
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Effect of anti-estrogens on the androgen receptor activity and cell proliferation in prostate cancer cells. | 2004 Dec |
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Recovery of serum prostate specific antigen value after interruption of antiandrogen therapy with allylestrenol for benign prostatic hyperplasia. | 2006 Jul |
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Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors. | 2007 Jun 1 |
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Application of a sensitive liquid chromatographic/tandem mass spectrometric method to a pharmacokinetic study of allylestrenol in healthy Chinese female volunteers. | 2008 Aug 1 |
Patents
Sample Use Guides
Adult: PO- The recommended dose is 10 to 40 mg per day 1 week.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15316697
PC-3 cells were transfected with a DNA mixture containing pMMTV-luc reporter (1 lg), pSG5AR (960 ng), and pRL-TK (40 ng), and grown for 24 h. Then, 5 nM of DHT with/ without allylestrenol was added. The cells were incubated for another 24 h and luciferase activities were measured.
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 15:12:38 GMT 2023
by
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on
Fri Dec 15 15:12:38 GMT 2023
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Record UNII |
I47VB5DZ8O
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C776
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WHO-ATC |
G03DC01
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WHO-VATC |
QG03DC01
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37723
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SUB05339MIG
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DTXSID9022574
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432-60-0
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CHEMBL2105618
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100000087457
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235905
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D000500
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125
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PRIMARY | |||
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525
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953
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C80270
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PRIMARY | |||
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DB01431
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I47VB5DZ8O
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207-082-9
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PRIMARY | |||
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ALLYLESTRENOL
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m1552
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PRIMARY | Merck Index |
Related Record | Type | Details | ||
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TARGET -> AGONIST |
Related Record | Type | Details | ||
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ACTIVE MOIETY |