FEZOLAMINE FUMARATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H23N3.C4H4O4
Molecular Weight	421.4889
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.CN(C)CCCN1C=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=ASDTZBJQJPTXLA-WLHGVMLRSA-N

InChI=1S/C20H23N3.C4H4O4/c1-22(2)14-9-15-23-16-19(17-10-5-3-6-11-17)20(21-23)18-12-7-4-8-13-18;5-3(6)1-2-4(7)8/h3-8,10-13,16H,9,14-15H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C20H23N3
Molecular Weight	305.4167
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3683802 | https://www.ncbi.nlm.nih.gov/pubmed/3668867

FEZOLAMINE is a nontricyclic antidepressant. It acts as a serotonin, norepinephrine, and dopamine reuptake inhibitor, with a preference for the former neurotransmitter. It was found to be effective and well tolerated in clinical trials but was never marketed.

Originator

Approval Year

PubMed

Title	Date	PubMed
3,4-Diphenyl-1H-pyrazole-1-propanamine antidepressants.	1985 Feb	3968690
Efficacy and safety of fezolamine in depressed patients.	1987	3683802
Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models.	1987 Oct	3668867

Patents

Sample Use Guides

In Vivo Use Guide

Therapy initiation at 100 mg/day. Maintenance dosage usually ranged between 100 and 450 mg/day.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:15:41 GMT 2023` Edited by `admin` on `Fri Dec 15 15:15:41 GMT 2023`
Record UNII	I1GX0BGV7P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FEZOLAMINE FUMARATE

Official Name

English

FEZOLAMINE FUMARATE [MART.]

Common Name

English

1H-PYRAZOLE-1-PROPANAMINE, N,N-DIMETHYL-3,4-DIPHENYL-, (E)-2-BUTENEDIOATE (1:1)

Systematic Name

English

WIN-41,528-2

Code

English

FEZOLAMINE FUMARATE [USAN]

Common Name

English

WIN 41528-2

Code

English

WIN-41528-2

Code

English

1-[3-(Dimethylamino)propyl]-3,4-diphenylpyrazole fumarate (1:1)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265