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Details

Stereochemistry ACHIRAL
Molecular Formula C20H23N3.C4H4O4
Molecular Weight 421.4889
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FEZOLAMINE FUMARATE

SMILES

OC(=O)\C=C\C(O)=O.CN(C)CCCN1C=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=ASDTZBJQJPTXLA-WLHGVMLRSA-N
InChI=1S/C20H23N3.C4H4O4/c1-22(2)14-9-15-23-16-19(17-10-5-3-6-11-17)20(21-23)18-12-7-4-8-13-18;5-3(6)1-2-4(7)8/h3-8,10-13,16H,9,14-15H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula C20H23N3
Molecular Weight 305.4167
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

FEZOLAMINE is a nontricyclic antidepressant. It acts as a serotonin, norepinephrine, and dopamine reuptake inhibitor, with a preference for the former neurotransmitter. It was found to be effective and well tolerated in clinical trials but was never marketed.

Approval Year

PubMed

PubMed

TitleDatePubMed
3,4-Diphenyl-1H-pyrazole-1-propanamine antidepressants.
1985 Feb
Efficacy and safety of fezolamine in depressed patients.
1987
Patents

Sample Use Guides

Therapy initiation at 100 mg/day. Maintenance dosage usually ranged between 100 and 450 mg/day.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:15:41 GMT 2023
Edited
by admin
on Fri Dec 15 15:15:41 GMT 2023
Record UNII
I1GX0BGV7P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FEZOLAMINE FUMARATE
MART.   USAN  
USAN  
Official Name English
FEZOLAMINE FUMARATE [MART.]
Common Name English
1H-PYRAZOLE-1-PROPANAMINE, N,N-DIMETHYL-3,4-DIPHENYL-, (E)-2-BUTENEDIOATE (1:1)
Systematic Name English
WIN-41,528-2
Code English
FEZOLAMINE FUMARATE [USAN]
Common Name English
WIN 41528-2
Code English
WIN-41528-2
Code English
1-[3-(Dimethylamino)propyl]-3,4-diphenylpyrazole fumarate (1:1)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2110688
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
PRIMARY
FDA UNII
I1GX0BGV7P
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
PRIMARY
PUBCHEM
6435397
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
PRIMARY
USAN
T-74
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
PRIMARY
MESH
C047153
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
PRIMARY
CAS
80410-37-3
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
PRIMARY
NCI_THESAURUS
C72781
Created by admin on Fri Dec 15 15:15:41 GMT 2023 , Edited by admin on Fri Dec 15 15:15:41 GMT 2023
PRIMARY
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