EVODENOSON

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H29N7O6
Molecular Weight	499.5197
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)N1CCC(CC#CC2=NC3=C(N=CN3[C@@H]4O[C@@H]([C@@H](O)[C@H]4O)C(=O)NC5CC5)C(N)=N2)CC1

InChI

InChIKey=SQJXTUJMBYVDBB-RQXXJAGISA-N

InChI=1S/C23H29N7O6/c1-35-23(34)29-9-7-12(8-10-29)3-2-4-14-27-19(24)15-20(28-14)30(11-25-15)22-17(32)16(31)18(36-22)21(33)26-13-5-6-13/h11-13,16-18,22,31-32H,3,5-10H2,1H3,(H,26,33)(H2,24,27,28)/t16-,17+,18-,22+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H29N7O6
Molecular Weight	499.5197
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26355151 | https://www.ncbi.nlm.nih.gov/pubmed/19909990 | https://www.ncbi.nlm.nih.gov/pubmed/20111666 | https://www.ncbi.nlm.nih.gov/pubmed/18937852 | https://www.ncbi.nlm.nih.gov/pubmed/17371980 | https://www.ncbi.nlm.nih.gov/pubmed/16622196

Evodenoson (ATL-313) is an agonist of adenosine A2A receptor. It exerts anti-inflammatory activity through activation of adenosine A2A receptors on CD4+ T cells and neutrophils. Evodenoson demonstrates efficacy in animal models of sepsis, myocardial infarction, allograft rejection and enteritis.

Originator

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:38:00 GMT 2025` Edited by `admin` on `Mon Mar 31 21:38:00 GMT 2025`
Record UNII	HZ03U10J2Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EVODENOSON

Official Name

English

evodenoson [INN]

Preferred Name

English

Evodenoson [WHO-DD]

Common Name

English

EVODENOSON [USAN]

Common Name

English

METHYL 4-(3-(6-AMINO-9-(N-CYCLOPROPYL-.BETA.-D-RIBOFURANOSYLURONAMIDE)-9H-PURIN-2-YL)PROP-2-YN-1-YL(PIPERIDINE-1-CARBOXYLATE

Common Name

English

1-PIPERIDINECARBOXYLIC ACID, 4-(3-(6-AMINO-9-(N-CYCLOPROPYL-.BETA.-DRIBOFURANURONAMIDOSYL)- 9H-PURIN-2-YL)-2-PROPYN-1-YL)-, METHYL ESTER

Common Name

English

1-PIPERIDINECARBOXYLIC ACID, 4-(3-(6-AMINO-9-(N-CYCLOPROPYL-.BETA.-D-RIBOFURANURONAMIDOSYL)-9H-PURIN-2-YL)-2-PROPYNYL)-, METHYL ESTER

Common Name

English

ATL-313

Code

English

ATL313

Code

English

METHYL 4-(3-(6-AMINO-9-(N-CYCLOPROPYL-.BETA.-D-RIBOFURANOSYLURONAMIDE)-9H-PURIN-2-YL)PROP- 2-YNYL)PIPERIDINE-1-CARBOXYLATE

Common Name

English

DE-112

Code

English

Code System Code Type Description

INN

9675