ISOFLUPREDONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H27FO5
Molecular Weight	378.4345
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=WAIJIHDWAKJCBX-BULBTXNYSA-N

InChI=1S/C21H27FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h5,7,9,14-16,23,25,27H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H27FO5
Molecular Weight	378.4345
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625

Isoflupredone is a veterinary drug used in cows, pigs and horses for the treatment of wide range of conditions: ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases, etc. The drug belongs to the class of corticosteroids and exerts its therapeutic effect by binding to glucocorticoid and mineralocorticoid receptors of animals.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Animal Glucocorticoid receptor 2 Target ID: Animal Glucocorticoid receptor Sources: http://www.merckvetmanual.com/mvm/pharmacology/anti-inflammatory_agents/corticosteroids.html	Binding Agent 1064
Animal Mineralocorticoid receptor 2 Target ID: Animal Mineralocorticoid receptor Sources: http://www.merckvetmanual.com/mvm/pharmacology/anti-inflammatory_agents/corticosteroids.html	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Bovine ketosis 2 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Curative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Musculoskeletal conditions 6 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Palliative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Allergic reactions 2 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Primary	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Infections 6 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Curative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Shock 9 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Palliative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Stress 11 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Palliative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959

PubMed

Title	Date	PubMed
Hypertension and hypokalaemia caused by 9 alpha-fluoroprednisolone in a nasal spray.	1979 Jun 16	87768

Patents

Sample Use Guides

In Vivo Use Guide

The usual intramuscular dose for cattle is 10 to 20 mg, according to the size of the animal and severity of the condition. This dose may be repeated in 12 to 24 hours if indicated. The usual intramuscular dose for horses is 5 to 20 mg repeated as necessary. The usual intramuscular dose for swine is 5 mg for a 300 pound animal.

Route of Administration: Intramuscular

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:46:22 GMT 2023` Edited by `admin` on `Fri Dec 15 15:46:22 GMT 2023`
Record UNII	HYS0B45Z2S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOFLUPREDONE

Official Name

English

Isoflupredone [WHO-DD]

Common Name

English

.DELTA.-FLUOROCORTISONE

Common Name

English

9.ALPHA.-FLUORO-.DELTA.1-CORTISOL

Common Name

English

isoflupredone [INN]

Common Name

English

(11.BETA.)-9-FLUORO-11,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

NSC-12174

Code

English

PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11,17,21-TRIHYDROXY-, (11.BETA.)-

Systematic Name

English

9-FLUOROPREDNISOLONE

Common Name

English

ISOFLUPREDONE [MI]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 524.1484C