Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H22N10O3 |
Molecular Weight | 510.5074 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NN=NN1N=CC2=CC(C(C3=CC=C(O)C=C3)C4=CC(C=NN5N=NN=C5C)=CC=C4O)=C(O)C=C2
InChI
InChIKey=BLUJRJMLDHEMRX-UHFFFAOYSA-N
InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3
Molecular Formula | C25H22N10O3 |
Molecular Weight | 510.5074 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Optical Activity | NONE |
VP-14637 (also known as MDT 637) was developed as an inhibitor of respiratory syncytial virus (RSV). RSV is the leading cause of respiratory tract infections in humans. VP-14637 participated in phase I clinical trial to evaluate the safety and pharmacokinetic profile of the drug in healthy human volunteers. However, further study was discontinued because of the strategic decision.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL612679 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25595685 |
PubMed
Title | Date | PubMed |
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VP-14637 ViroPharma. | 2000 Dec |
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Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. | 2003 May |
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Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. | 2005 Jun |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT01355016
Inhaled doses of MDT-637 (VP-14637) over a 24 hour period
Route of Administration:
Respiratory
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:15:41 GMT 2023
by
admin
on
Fri Dec 15 16:15:41 GMT 2023
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Record UNII |
HCW4G0O030
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Record Status |
Validated (UNII)
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Record Version |
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