MDT-637

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H22N10O3
Molecular Weight	510.5074
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NN=NN1\N=C\C2=CC(C(C3=CC=C(O)C=C3)C4=C(O)C=CC(\C=N\N5N=NN=C5C)=C4)=C(O)C=C2

InChI

InChIKey=BLUJRJMLDHEMRX-BMNRKXRESA-N

InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3/b26-13+,27-14+

HIDE SMILES / InChI

Molecular Formula	C25H22N10O3
Molecular Weight	510.5074
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11249694 | https://clinicaltrials.gov/ct2/show/NCT01355016 | http://investors.gilead.com/news-releases/news-release-details/gilead-and-microdose-therapeutx-announce-license-and

VP-14637 (also known as MDT 637) was developed as an inhibitor of respiratory syncytial virus (RSV). RSV is the leading cause of respiratory tract infections in humans. VP-14637 participated in phase I clinical trial to evaluate the safety and pharmacokinetic profile of the drug in healthy human volunteers. However, further study was discontinued because of the strategic decision.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Respiratory syncytial virus 4 Target ID: CHEMBL612679 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25595685	Inhibitor 8504

PubMed

Title	Date	PubMed
Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms.	2005-06	15917547
Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein.	2003-05	12692208
VP-14637 ViroPharma.	2000-12	11249694

Sample Use Guides

In Vivo Use Guide

Inhaled doses of MDT-637 (VP-14637) over a 24 hour period

Route of Administration: Respiratory

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:23:20 GMT 2025` Edited by `admin` on `Mon Mar 31 18:23:20 GMT 2025`
Record UNII	HCW4G0O030
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENOL, 2,2'-((4-HYDROXYPHENYL)METHYLENE)BIS(4-(((5-METHYL-1H-TETRAZOL-1-YL)IMINO)METHYL)-

Preferred Name

English

MDT-637

Common Name

English

VP-14637

Common Name

English

Code System Code Type Description

SMS_ID

300000051216