Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H22N10O3.2H2O |
| Molecular Weight | 546.5379 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.CC1=NN=NN1\N=C\C2=CC(C(C3=CC=C(O)C=C3)C4=C(O)C=CC(\C=N\N5N=NN=C5C)=C4)=C(O)C=C2
InChI
InChIKey=ZXRJTGIAVCKALY-OBXOIMMSSA-N
InChI=1S/C25H22N10O3.2H2O/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35;;/h3-14,25,36-38H,1-2H3;2*1H2/b26-13+,27-14+;;
| Molecular Formula | C25H22N10O3 |
| Molecular Weight | 510.5074 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Optical Activity | ( + / - ) |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
VP-14637 (also known as MDT 637) was developed as an inhibitor of respiratory syncytial virus (RSV). RSV is the leading cause of respiratory tract infections in humans. VP-14637 participated in phase I clinical trial to evaluate the safety and pharmacokinetic profile of the drug in healthy human volunteers. However, further study was discontinued because of the strategic decision.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. | 2005-06 |
|
| Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. | 2003-05 |
|
| VP-14637 ViroPharma. | 2000-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 20:48:47 GMT 2025
by
admin
on
Wed Apr 02 20:48:47 GMT 2025
|
| Record UNII |
2Q5G7YB8CD
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
2Q5G7YB8CD
Created by
admin on Wed Apr 02 20:48:47 GMT 2025 , Edited by admin on Wed Apr 02 20:48:47 GMT 2025
|
PRIMARY | |||
|
1527480-52-9
Created by
admin on Wed Apr 02 20:48:47 GMT 2025 , Edited by admin on Wed Apr 02 20:48:47 GMT 2025
|
PRIMARY | |||
|
171390247
Created by
admin on Wed Apr 02 20:48:47 GMT 2025 , Edited by admin on Wed Apr 02 20:48:47 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
SALT/SOLVATE -> PARENT |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|