ICODULINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10N2OS
Molecular Weight	206.264
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(O)=C(NC2=NC=CS2)C=C1

InChI

InChIKey=UTHOTQDPKFKRKG-UHFFFAOYSA-N

InChI=1S/C10H10N2OS/c1-7-2-3-8(9(13)6-7)12-10-11-4-5-14-10/h2-6,13H,1H3,(H,11,12)

HIDE SMILES / InChI

Molecular Formula	C10H10N2OS
Molecular Weight	206.264
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2514693 | https://adisinsight.springer.com/drugs/800003340 | https://www.ncbi.nlm.nih.gov/pubmed/2514693

Icoduline (previously known as CBS-113 A) is a dual inhibitor of 5-lipoxygenase and cyclo-oxygenase with anti-inflammatory properties. This drug was potentially useful in ophthalmology and as an alternative to glucocorticoids. In addition, icoduline was useful to treat skin disorders. The drug participated in the clinical trial for eye disorders in France; however, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Electrochemical oxidation of CBS-113 A, a new anti-inflammatory drug: applicability to liquid chromatography-electrochemical detection.	1995-08	8573639
2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 1st communication: in vitro studies.	1989-10	2514692
2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 2nd communication: anti-inflammatory activity.	1989-10	2514693
Effects of lipoxygenase inhibitors on the arachidonic acid cascade in the rabbit cornea after injury.	1988	3139810

Patents

Sample Use Guides

In Vivo Use Guide

0.1%

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:03:39 GMT 2025` Edited by `admin` on `Mon Mar 31 18:03:39 GMT 2025`
Record UNII	H91334173C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

icoduline [INN]

Preferred Name

English

ICODULINE

Official Name

English

6-(2-THIAZOLYLAMINO)-M-CRESOL

Systematic Name

English

ICODULINUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257