Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H10N2OS.ClH |
| Molecular Weight | 242.725 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC1=CC=C(NC2=NC=CS2)C(O)=C1
InChI
InChIKey=OAQDENGCTUPZEL-UHFFFAOYSA-N
InChI=1S/C10H10N2OS.ClH/c1-7-2-3-8(9(13)6-7)12-10-11-4-5-14-10;/h2-6,13H,1H3,(H,11,12);1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C10H10N2OS |
| Molecular Weight | 206.264 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Icoduline (previously known as CBS-113 A) is a dual inhibitor of 5-lipoxygenase and cyclo-oxygenase with anti-inflammatory properties. This drug was potentially useful in ophthalmology and as an alternative to glucocorticoids. In addition, icoduline was useful to treat skin disorders. The drug participated in the clinical trial for eye disorders in France; however, this study was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Electrochemical oxidation of CBS-113 A, a new anti-inflammatory drug: applicability to liquid chromatography-electrochemical detection. | 1995-08 |
|
| 2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 1st communication: in vitro studies. | 1989-10 |
|
| 2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 2nd communication: anti-inflammatory activity. | 1989-10 |
|
| Effects of lipoxygenase inhibitors on the arachidonic acid cascade in the rabbit cornea after injury. | 1988 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:13:25 GMT 2025
by
admin
on
Mon Mar 31 18:13:25 GMT 2025
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| Record UNII |
FRM2IBI8XA
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID30911913
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163834
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FRM2IBI8XA
Created by
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110952-54-0
Created by
admin on Mon Mar 31 18:13:25 GMT 2025 , Edited by admin on Mon Mar 31 18:13:25 GMT 2025
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PARENT -> SALT/SOLVATE |
