Renadirsen sodium

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 16:52:16 GMT 2023` Edited by `admin` on `Sat Dec 16 16:52:16 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	H5MKY4U4D5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Renadirsen sodium

Common Name

English

RNA, (P-thio)([2′,6′-anhydro-5′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-Gm-(3′→4′)-[2′,6′-anhydro-5′-deoxy-4′-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3′→4′)-[2′,6′-anhydro-5′-deoxy-4′-C-(hydroxymethyl)

Systematic Name

English

Code System Code Type Description

FDA UNII

H5MKY4U4D5

Created by admin on Sat Dec 16 16:52:16 GMT 2023 , Edited by admin on Sat Dec 16 16:52:16 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O,4'-ethylene bridged Ribose	1_1;1_3-1_4;1_7-1_8;1_11;1_13-1_14;1_17-1_18	10 / 18
2'-O-Methyl-Ribose	1_2;1_5-1_6;1_9-1_10;1_12;1_15-1_16	8 / 18

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_18	17 / 17

Related Record Type Details


					4RW6WRD7SW

Renadirsen

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					4RW6WRD7SW

Renadirsen

ACTIVE MOIETY

Amount:


					4RW6WRD7SW

Renadirsen

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_18]	3'-TERMINUS	2'-O,4'-C-(ethane-1,2-diyl)-5-methyl-3'-(O-(2-hydroxyethyl)-P-thio)-3'-cytidylate sodium	J44UD6X65C
NUCLEOSIDE BASE SUBSTITUTION	[1_4] [1_11]	SITE_SPECIFIC	THYMINE	QR26YLT7LT
NUCLEOSIDE BASE SUBSTITUTION	[1_1] [1_3] [1_7] [1_8] [1_13] [1_14] [1_17]	SITE_SPECIFIC	5-METHYLCYTOSINE	6R795CQT4H