U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
It is known that Vitamin E, traditionally known as α¬ tocopherol, is a mixture of eight different compounds, four tocopherols and four tocotrienols, each one being designated as α, β, γ and δ forms. The two groups differ in the hydrophobic tridecyl side chain which is saturated (phytyl) in tocopherols and unsaturated having three double bonds (geranyl) in tocotrienols. During the last few years, it has been found that all the eight forms are biologically active and perform specific functions. Clinical research has shown that mixture of tocotrienols and tocopherols offer synergistic protective action against heart ailments and cancer that is not exclusively offered by α¬tocopherol. The other advantage of mixed tocopherols and tocotrienols is their role in slowing down aging. Diseases like diabetes 1 and 2, autoimmune diseases, bacterial and viral infections, Alzheimer disease, fungal (Candida) infections are prevented by these compounds. It helps in the maintenance of bones, muscles, eyes (vision), memory, sleep, lungs, infertility, skin and wrinkles. Although all forms of Vitamin E exhibit antioxidant activity, it is known that the antioxidant activity of vitamin E is not sufficient to explain the vitamin's biological activity. Vitamin E's anti-atherogenic activity involves the inhibition of the oxidation of LDL and the accumulation of oxLDL in the arterial wall. Vitamin E's antithrombotic and anticoagulant activities involves the downregulation of the expression of intracellular cell adhesion molecule(ICAM)-1 and vascular cell adhesion molecule(VCAM)-1 that lowers the adhesion of blood components to the endothelium. Its antioxidant effects explain the neuroprotective effects of vitamin E. The immunomodulatory effects of Vitamin E have been demonstrated in vitro, where alpha-tocopherol increases mitogenic response of T lymphocytes from aged mice. The mechanism of this response by vitamin E is not well understood, however it has been suggested that vitamin E itself may have mitogenic activity independent of its antioxidant activity. The mechanism of action of vitamin E's antiviral effects (primarily against HIV-1) involves its antioxidant activity. Vitamin E reduces oxidative stress, which is thought to contribute to HIV-1 pathogenesis, as well as to the pathogenesis of other viral infections. Vitamin E also affects membrane integrity and fluidity and, since HIV-1 is a membraned virus, altering membrane fluidity of HIV-1 may interfere with its ability to bind to cell-receptor sites, thus decreasing its infectivity.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: O94759
Gene ID: 7226.0
Gene Symbol: TRPM2
Target Organism: Homo sapiens (Human)
Target ID: P14174
Gene ID: 4282.0
Gene Symbol: MIF
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
REVERSE IT KIT

Approved Use

SUNSCREEN

Launch Date

1.39968001E12
Palliative
M.V.I. PEDIATRIC

Approved Use

This formulation is indicated as daily multivitamin maintenance dosage for infants and children up to 11 years of age receiving parenteral nutrition. It is also indicated in other situations where administration by the intravenous route is required. Such situations include surgery, extensive burns, fractures and other trauma, severe infectious diseases, and comatose states, which may provoke a “stress” situation with profound alterations in the body’s metabolic demands and consequent tissue depletion of nutrients. The physician should not await the development of clinical signs of vitamin deficiency before initiating vitamin therapy. M.V.I. Pediatric (reconstituted and administered in intravenous fluids under proper dilution) contributes intake of these necessary vitamins toward maintaining the body’s normal resistance and repair processes. Patients with multiple vitamin deficiencies or with markedly increased requirements may be given multiples of the daily dosage for two or more days as indicated by the clinical status. Blood vitamin concentrations should be monitored to ensure maintenance of adequate levels, particularly in patients receiving parenteral multivitamins as their sole source of vitamins for long periods of time.

Launch Date

9.6949443E11
PubMed

PubMed

TitleDatePubMed
[Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography].
2001
The antioxidant network of the stratum corneum.
2001
Bioconversion of vitamin E acetate in human skin.
2001
The use of hydrogen peroxide to enhance the efficacy of doxorubicin hydrochloride in a murine bladder tumor cell line.
2001 Apr
The impact of phospholipid transfer protein (PLTP) on HDL metabolism.
2001 Apr
Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters.
2001 Apr
Interfacial properties of phosphatidylcholine bilayers containing vitamin E derivatives.
2001 Feb
Antioxidant and prooxidant roles for beta-carotene, alpha-tocopherol and ascorbic acid in human lung cells.
2001 Feb
Dietary patterns, nutrient intake and gastric cancer in a high-risk area of Italy.
2001 Feb
Vitamin E administration and reversal of neurological deficits in protein-energy malnutrition.
2001 Feb
Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries.
2001 Feb
Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations.
2001 Feb
Normobaric hyperoxic stress in budgerigars: non-enzymic antioxidants.
2001 Feb
A comparison of the kinetics of low-density lipoprotein oxidation induced by copper or by gamma-rays: influence of radiation dose-rate and copper concentration.
2001 Feb
Ascorbic acid status and subsequent diastolic and systolic blood pressure.
2001 Feb
Hereditary vitamin-E deficiency.
2001 Feb
Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma.
2001 Feb
Soluble adhesion molecules, endothelial function and vitamin E in type 1 diabetes.
2001 Feb
Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones.
2001 Feb
The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells.
2001 Feb 26
[Differences in plasma antioxidants according to socioeconomic level in Chilean women].
2001 Jan
Regulation of heme oxygenase activity in rat liver during oxidative stress induced by cobalt chloride and mercury chloride.
2001 Jan
Oxidative insult in sheep red blood cells induced by T-butyl hydroperoxide: the roles of glutathione and glutathione peroxidase.
2001 Jan
Longitudinal vitamin and homocysteine levels in normal pregnancy.
2001 Jan
Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components.
2001 Jan
Removal of fat from cow's milk decreases the vitamin E contents of the resulting dairy products.
2001 Jan
Cacao liquor polyphenols reduce oxidative stress without maintaining alpha-tocopherol levels in rats fed a vitamin E-deficient diet.
2001 Jan
Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E.
2001 Jan
Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status.
2001 Jan
Hypomethylation of p53 in peripheral blood DNA is associated with the development of lung cancer.
2001 Jan
Intravenous infusion of iron and tetrahydrofolate does not influence intrauterine uteroferrin and secreted folate-binding protein content in swine.
2001 Jan
DNA strand breakage and oxygen tension: effects of beta-carotene, alpha-tocopherol and ascorbic acid.
2001 Mar
Diazepam submicron emulsions containing soya-bean oil and intended for oral or rectal delivery.
2001 Mar
Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes.
2001 Mar
Antioxidant status affects color stability and tenderness of calcium chloride-injected beef.
2001 Mar
Multivariate patterns of biochemical responses of Pinus ponderosa trees at field plots in the San Bernardino Mountains, southern California.
2001 Mar
Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.
2001 Mar
Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate.
2001 Mar
Antioxidant activity of resveratrol compared with common food additives.
2001 Mar
Preparation and value assignment of Standard Reference Material 968c Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum.
2001 Mar
Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria.
2001 Mar
Fiberoptic and conventional phototherapy effects on the skin of premature infants.
2001 Mar
Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil.
2001 Mar
Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E, and oxidative stress in the rat liver.
2001 Mar 1
No reduction of alpha-tocopherol quinone by glutathione in rat liver microsomes.
2001 Mar 15
Growth reduction in glioma cells after treatment with tetradecylthioacetic acid: changes in fatty acid metabolism and oxidative status.
2001 Mar 15
Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women.
2001 Mar 15
t-Butyl hydroperoxide and oxidized low density lipoprotein enhance phospholipid hydrolysis in lipopolysaccharide-stimulated retinal pericytes.
2001 Mar 30
Antioxidants prevent ethanol-induced contractions of canine cerebral vascular smooth muscle: relation to alcohol-induced brain injury.
2001 Mar 30
Effects of vitamin E on lipid peroxidation in healthy persons.
2001 Mar 7
Patents

Sample Use Guides

For vitamin E deficiency: a typical dose in adults is RRR-alpha tocopherol (natural vitamin E) 60-75 IU per day. For the movement disorder called tardive dyskinesia: RRR-alpha-tocopherol (natural vitamin E) 1600 IU daily. For improving male fertility: vitamin E 200-600 IU daily. For Alzheimer's disease: up to 2000 IU daily. Combination therapy of donepezil (Aricept) 5 mg and vitamin E 1000 IU per day has been used for slowing memory decline in people with Alzheimer's disease. For liver disease called non-alcoholic steatohepatitis: 800 IU daily in adults has been used; 400-1200 IU daily has been used in children. For early Huntington's chorea: RRR-alpha-tocopherol (natural vitamin E) 3000 IU. For rheumatoid arthritis pain: vitamin E 600 IU twice daily. For preventing nerve damage caused by cisplatin: vitamin E (alpha-tocopherol) 300 mg daily with each chemotherapy treatment and for up to 3 months after stopping cisplatin therapy. For improving effectiveness of nitrates used for heart disease: vitamin E 200 mg three times daily.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment:: In RAW264.7 cells, vitamin E-rich nanoemulsion significantly enhanced the secretion of Th1 cytokines and down-regulated the secretion of Th2 cytokine. In a co-culture system, vitamin E-rich nanoemulsion induced a high apoptosis rate in MDA-MB-231 cells as compared with vitamin E-low nanoemulsion.
Unknown
Substance Class Mixture
Created
by admin
on Sat Jun 26 17:00:09 UTC 2021
Edited
by admin
on Sat Jun 26 17:00:09 UTC 2021
Record UNII
H4N855PNZ1
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
ALPHA-TOCOPHEROL
Preferred Name English
.ALPHA.-TOCOPHEROL
II  
Common Name English
ALPHA TOCOPHEROL [USP-RS]
Common Name English
.ALPHA.-TOCOPHEROL [II]
Common Name English
J203.513H
Code English
VITAMIN E [MI]
Common Name English
ALPHA-TOCOPHEROL, UNSPECIFIED FORM
Common Name English
.ALPHA.-TOCOPHEROL, UNSPECIFIED FORM
Common Name English
VITAMIN E (AS ALPHA TOCOPHEROL)
Common Name English
ALPHA TOCOPHEROL
Common Name English
AQUASOL E
Common Name English
ENVIROSE 100
Common Name English
ALPHA-TOCOPHEROLS
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 335111
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
DSLD 2421 (Number of products:1242)
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
EU-Orphan Drug EU/3/17/1832
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
LOINC 14590-4
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
LOINC 74513-3
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
LIVERTOX 30
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
LOINC 20681-3
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
FDA ORPHAN DRUG 678719
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
LOINC 1823-4
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C74960
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
MERCK INDEX
M11488
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY Merck Index
MESH
D024502
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
USP_CATALOG
1667600
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY USP-RS
RXCUI
237099
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
WIKIPEDIA
ALPHA-TOCOPHEROL
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
FDA UNII
H4N855PNZ1
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
ECHA (EC/EINECS)
215-798-8
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
ChEMBL
CHEMBL47
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
CAS
1406-18-4
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
EVMPD
SUB16355MIG
Created by admin on Sat Jun 26 17:00:09 UTC 2021 , Edited by admin on Sat Jun 26 17:00:09 UTC 2021
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
PARENT -> CONSTITUENT ALWAYS PRESENT
Related Record Type Details
ACTIVE MOIETY
Definition References