TROMANTADINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H28N2O2
Molecular Weight	280.4057
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN(C)CCOCC(=O)NC12CC3CC(CC(C3)C1)C2

InChI

InChIKey=UXQDWARBDDDTKG-UHFFFAOYSA-N

InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)

HIDE SMILES / InChI

Molecular Formula	C16H28N2O2
Molecular Weight	280.4057
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Tromantadine HCl under brand name Virumerz is used to treat the herpes simplex virus by inhibiting the cellular process such as glycoprotein processing, which occurs after the synthesis of the fusion protein but before its expression on the cell surface.

Approval Year

PubMed

PubMed

Show entries

Title	Date	PubMed
Tromantadine: inhibitor of early and late events in herpes simplex virus replication.	1982 Dec	6297383
Contact dermatitis from topical antiviral drugs.	2001 May	11298689
Separation methods for tricyclic antiviral drugs.	2001 Nov 25	11817035
Dimethyl sulfoxide blocks herpes simplex virus-1 productive infection in vitro acting at different stages with positive cooperativity. Application of micro-array analysis.	2002 May 24	12052246
Nona-arginine facilitates delivery of quantum dots into cells via multiple pathways.	2010	21048930