TROMANTADINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H28N2O2
Molecular Weight	280.4057
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TROMANTADINE

Structure Search

SMILES

CN(C)CCOCC(=O)NC12CC3CC(CC(C3)C1)C2

InChI

InChIKey=UXQDWARBDDDTKG-UHFFFAOYSA-N

InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)

HIDE SMILES / InChI

Molecular Formula	C16H28N2O2
Molecular Weight	280.4057
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6297383 | https://www.ncbi.nlm.nih.gov/pubmed/2686658

Tromantadine HCl under brand name Virumerz is used to treat the herpes simplex virus by inhibiting the cellular process such as glycoprotein processing, which occurs after the synthesis of the fusion protein but before its expression on the cell surface.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Tromantadine: inhibitor of early and late events in herpes simplex virus replication.	1982 Dec	6297383
Contact dermatitis from topical antiviral drugs.	2001 May	11298689
Separation methods for tricyclic antiviral drugs.	2001 Nov 25	11817035
[Clinical and epidemiological aspects and current recommendations on treatment of genital herpes].	2002 Dec	12602261
Dimethyl sulfoxide blocks herpes simplex virus-1 productive infection in vitro acting at different stages with positive cooperativity. Application of micro-array analysis.	2002 May 24	12052246
A critical role for endocytosis in Wnt signaling.	2006 Jul 6	16824228
Nona-arginine facilitates delivery of quantum dots into cells via multiple pathways.	2010	21048930
The susceptibility of magpies to a highly pathogenic avian influenza virus subtype H5N1.	2010 Jun	20460661

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:49 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:49 GMT 2023`
Record UNII	H191JFG8WA
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TROMANTADINE

Official Name

English

tromantadine [INN]

Common Name

English

Tromantadine [WHO-DD]

Common Name

English

TROMANTADINE [MI]

Common Name

English

TROMANTADINE [II]

Common Name

English

N-1-ADAMANTYL-2-(2-(DIMETHYLAMINO)ETHOXY)ACETAMIDE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QJ05AC03

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

WHO-ATC

D06BB02

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

WHO-ATC

J05AC03

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

NCI_THESAURUS

C281

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

WHO-VATC

QD06BB02

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

Code System Code Type Description

DRUG CENTRAL

3634

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

PRIMARY

SMS_ID

100000076957

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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PUBCHEM

64377

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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WIKIPEDIA

TROMANTADINE

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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NCI_THESAURUS

C81608

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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FDA UNII

H191JFG8WA

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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MESH

C004279

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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EVMPD

SUB11335MIG

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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ECHA (EC/EINECS)

258-770-0

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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ChEMBL

CHEMBL1742451

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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MERCK INDEX

m11220

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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Merck Index

INN

3234

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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RXCUI

38868

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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RxNorm

EPA CompTox

DTXSID00202062

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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CAS

53783-83-8

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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DRUG BANK

DB13288

Created by admin on Fri Dec 15 15:35:49 GMT 2023 , Edited by admin on Fri Dec 15 15:35:49 GMT 2023

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TROMANTADINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					H191JFG8WA

ACTIVE MOIETY