TROMANTADINE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H28N2O2.ClH
Molecular Weight	316.867
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN(C)CCOCC(=O)NC12CC3CC(CC(C3)C1)C2

InChI

InChIKey=BPRCWSNCXPHMIW-UHFFFAOYSA-N

InChI=1S/C16H28N2O2.ClH/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16;/h12-14H,3-11H2,1-2H3,(H,17,19);1H

HIDE SMILES / InChI

Molecular Formula	C16H28N2O2
Molecular Weight	280.4057
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6297383 | https://www.ncbi.nlm.nih.gov/pubmed/2686658

Tromantadine HCl under brand name Virumerz is used to treat the herpes simplex virus by inhibiting the cellular process such as glycoprotein processing, which occurs after the synthesis of the fusion protein but before its expression on the cell surface.

Approval Year

PubMed

Title	Date	PubMed
The susceptibility of magpies to a highly pathogenic avian influenza virus subtype H5N1.	2010-06	20460661
Nona-arginine facilitates delivery of quantum dots into cells via multiple pathways.	2010	21048930
A critical role for endocytosis in Wnt signaling.	2006-07-06	16824228
[Clinical and epidemiological aspects and current recommendations on treatment of genital herpes].	2002-12	12602261
Dimethyl sulfoxide blocks herpes simplex virus-1 productive infection in vitro acting at different stages with positive cooperativity. Application of micro-array analysis.	2002-05-24	12052246
Separation methods for tricyclic antiviral drugs.	2001-11-25	11817035
Contact dermatitis from topical antiviral drugs.	2001-05	11298689
Tromantadine: inhibitor of early and late events in herpes simplex virus replication.	1982-12	6297383

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:48:34 GMT 2025` Edited by `admin` on `Mon Mar 31 18:48:34 GMT 2025`
Record UNII	H09LUS437B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-(2-DIMETHYLAMINOETHOXY)-N-(TRICYCLO(3.3.1.13,7)(DEC-1-YL)ACETAMIDE HYDROCHLORIDE

Preferred Name

English

TROMANTADINE HYDROCHLORIDE

Common Name

English

Tromantadine hydrochloride [WHO-DD]

Common Name

English

TROMANTADINE HCL

Common Name

English

TROMANTADINE HYDROCHLORIDE [MART.]

Common Name

English

N-1-ADAMANTYL-2-(2-DIMETHYLAMINOETHOXY)ACETAMIDE HYDROCHLORIDE

Systematic Name

English

TROMANTADINE HYDROCHLORIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C281