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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:26:04 GMT 2025` Edited by `admin` on `Wed Apr 02 11:26:04 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY FUSION PROTEIN
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	GTN7CK8Y7C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

gamma 1 heavy chain (1-450) [VH (Homo sapiens IGHV3-66*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.11] (31-35.50-66.99-109)) (1-120) -Homo sapiens IGHG1*03 (CH1 (121-218), hinge (219-233), CH2 S<sup>301</sup>>A, E<sup>336</sup>>A, K<sup>337</sup>>A (234-343),

Preferred Name

English

Vislarafusp Alfa

Common Name

English

Immunoglobulin G1 [351-alanine,386-alanine,387-alanine] anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal IMM2902 ?1-chain), disulfide with 1-125-signal regulatory protein ? [80-alanine] (human isoform 4 variant) fusion pr

Common Name

English

human signal regulatory protein alpha (SIRP?) fragment, anti-(human CD47, integrin associated protein (IAP)), fused via a (G4S)3 peptide linker to the N-terminus of both light chains of a humanized immunoglobulin G1-kappa anti-(human epidermal growth fac

Common Name

English

IMM-2902

Code

English

IMM2902

Code

English

vislarafusp alfa [INN]

Common Name

English

Code System Code Type Description

FDA UNII

GTN7CK8Y7C

Created by admin on Wed Apr 02 11:26:04 GMT 2025 , Edited by admin on Wed Apr 02 11:26:04 GMT 2025

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CAS

2850355-96-1

Created by admin on Wed Apr 02 11:26:04 GMT 2025 , Edited by admin on Wed Apr 02 11:26:04 GMT 2025

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NCI_THESAURUS

C185132

Created by admin on Wed Apr 02 11:26:04 GMT 2025 , Edited by admin on Wed Apr 02 11:26:04 GMT 2025

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SMS_ID

300000054758

Created by admin on Wed Apr 02 11:26:04 GMT 2025 , Edited by admin on Wed Apr 02 11:26:04 GMT 2025

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INN

12965

Created by admin on Wed Apr 02 11:26:04 GMT 2025 , Edited by admin on Wed Apr 02 11:26:04 GMT 2025

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From	To
2_223	4_354
1_223	3_354
4_163	4_228
4_25	4_91
3_163	3_228
3_25	3_91
1_232	2_232
1_229	2_229
2_370	2_428
2_264	2_324
2_147	2_203
2_22	2_96
1_370	1_428
1_264	1_324
1_147	1_203
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					GTN7CK8Y7C

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ACTIVE MOIETY

Comments:

IMM2902 is a recombinant bispecific antibody against CD47 and HER2. It can bind to HER2 on the tumor cell membrane and to CD47 to block the binding of CD47 to SIRP?, deregulating the immunosuppression of tumor cells on macrophages. Moreover, this bispecific antibody can bind to Fc receptors on the surface of natural killer cells (NK cells) and macrophages to induce antibodydependent cellular phagocytosis (ADCP) and antibody-dependent cell-mediated cytotoxicity (ADCC) to remove tumor cells

Interaction Type:

PRECLINICAL

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_1] [4_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL		C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL