PAVURUTAMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:51:21 GMT 2025` Edited by `admin` on `Wed Apr 02 02:51:21 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	BISPECIFIC T CELL ENGAGER
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	GLR3JG8TZU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PAVURUTAMAB

Official Name

English

pavurutamab [INN]

Preferred Name

English

PAVURUTAMAB [USAN]

Common Name

English

AMG701

Code

English

ANTI-BCMA X ANTI-CD3 BITE AMG 701

Common Name

English

AMG-701

Code

English

IMMUNOGLOBULIN SCFV-SCFV-SCFC, ANTI-(HOMO SAPIENS TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17 (B-CELL MATURATION PROTEIN, CD269_ANTIGEN)) TNR17 AND ANTI-(HOMO SAPIENS T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN (T-CELL SURFACE ANTIGEN T3/LEU-4

Common Name

English

BCMA/CD3-DIRECTED BISPECIFIC T-CELL ENGAGER ANTIBODY AMG 701

Common Name

English

IMMUNOGLOBULIN, ANTI-(HUMAN TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY PROTEIN TNFRSF17) (HUMAN MONOCLONAL BRA-HWZV 1 SINGLE-CHAIN VARIABLE FRAGMENT VH1-(GGGGS)3-VL1) FUSION PROTEIN WITH PEPTIDE LINKER (GGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN ANTI-(HUM

Common Name

English

Pavurutamab [WHO-DD]

Common Name

English

ANTI-BCMA X ANTI-CD3 BITE (BISPECIFIC T CELL ENGAGER) ANTIBODY CONSTRUCT

Common Name

English

ANTI-BCMA/CD3 BITE ANTIBODY AMG 701

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

669618

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C147028

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

PRIMARY

FDA UNII

GLR3JG8TZU

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

PRIMARY

USAN

HI-217

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

PRIMARY

CAS

2250292-39-6

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

PRIMARY

CAS

2298375-18-3

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

SUPERSEDED

SMS_ID

300000028756

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

PRIMARY

INN

11290

Created by admin on Wed Apr 02 02:51:21 GMT 2025 , Edited by admin on Wed Apr 02 02:51:21 GMT 2025

PRIMARY

From	To
1_44	1_236
1_22	1_96
1_159	1_224
1_271	1_347
1_411	1_479
1_508	1_765
1_511	1_768
1_543	1_603
1_574	1_584
1_800	1_860
1_649	1_707
1_906	1_964
1_831	1_841

Related Record Type Details


					ZLW14X2D30

CD3

TARGET -> ACTIVATOR

Amount:


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->LIGAND

Amount:

Related Record Type Details


					GLR3JG8TZU

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_986]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL