C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 11:43:10 UTC 2023` Edited by `admin` on `Sat Dec 16 11:43:10 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	GJD9I3123C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1

Common Name

English

C5AR

Common Name

English

CD88

Common Name

English

C5R1

Common Name

English

C5a anaphylatoxin chemotactic receptor (C5a-R; C5aR)

Common Name

English

C5AR1 expressed protein

Common Name

English

Code System Code Type Description

FDA UNII

GJD9I3123C

Created by admin on Sat Dec 16 11:43:10 UTC 2023 , Edited by admin on Sat Dec 16 11:43:10 UTC 2023

PRIMARY

UNIPROT

P21730

Created by admin on Sat Dec 16 11:43:10 UTC 2023 , Edited by admin on Sat Dec 16 11:43:10 UTC 2023

PRIMARY

PHAROS

P21730

Created by admin on Sat Dec 16 11:43:10 UTC 2023 , Edited by admin on Sat Dec 16 11:43:10 UTC 2023

PRIMARY

From	To
1_109	1_188

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_5

Related Record Type Details


					H94WRL71FP

NDT-9513727

INVERSE AGONIST->TARGET

Amount:


					DC25O3L7KZ

PMX-205

INHIBITOR -> TARGET

Interaction Type:

ANTAGONIST

Qualification:

IC50

Amount:


					O880NM097T

AVACOPAN

INHIBITOR -> TARGET

Amount:


					DW4CE8MKS9

AVDORALIMAB

INHIBITOR -> TARGET

Comments:

IPH5401 is a therapeutic human antibody that specifically binds and blocks C5a receptors (C5aR) expressed on subsets of myeloid-derived suppressor cells (MDSC) and neutrophils. IPH5401 blocks the binding of C5a to C5aR, thereby reducing the accumulation and activation of MDSC and neutrophils in tumors. Treatment with IPH5401 may unleash anti-tumor activities of T cells and NK cells.

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL