U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:43:10 GMT 2023
Edited
by admin
on Sat Dec 16 11:43:10 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
GJD9I3123C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1
Common Name English
C5AR
Common Name English
CD88
Common Name English
C5R1
Common Name English
C5a anaphylatoxin chemotactic receptor (C5a-R; C5aR)
Common Name English
C5AR1 expressed protein
Common Name English
Code System Code Type Description
FDA UNII
GJD9I3123C
Created by admin on Sat Dec 16 11:43:10 GMT 2023 , Edited by admin on Sat Dec 16 11:43:10 GMT 2023
PRIMARY
UNIPROT
P21730
Created by admin on Sat Dec 16 11:43:10 GMT 2023 , Edited by admin on Sat Dec 16 11:43:10 GMT 2023
PRIMARY
PHAROS
P21730
Created by admin on Sat Dec 16 11:43:10 GMT 2023 , Edited by admin on Sat Dec 16 11:43:10 GMT 2023
PRIMARY
From To
1_109 1_188
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_5
Related Record Type Details
INVERSE AGONIST->TARGET
INHIBITOR -> TARGET
ANTAGONIST
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IPH5401 is a therapeutic human antibody that specifically binds and blocks C5a receptors (C5aR) expressed on subsets of myeloid-derived suppressor cells (MDSC) and neutrophils. IPH5401 blocks the binding of C5a to C5aR, thereby reducing the accumulation and activation of MDSC and neutrophils in tumors. Treatment with IPH5401 may unleash anti-tumor activities of T cells and NK cells.
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL