U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 19:44:55 UTC 2023
Edited
by admin
on Thu Jul 06 19:44:55 UTC 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
DW4CE8MKS9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AVDORALIMAB
INN  
Official Name English
NNC-0215-0384
Code English
ANTI-C5AR-215
Common Name English
NN-8210
Code English
Avdoralimab [WHO-DD]
Common Name English
avdoralimab [INN]
Common Name English
IPH-5401
Code English
IPH5401
Common Name English
Code System Code Type Description
NCI_THESAURUS
C163020
Created by admin on Thu Jul 06 19:44:55 UTC 2023 , Edited by admin on Thu Jul 06 19:44:55 UTC 2023
PRIMARY
INN
11081
Created by admin on Thu Jul 06 19:44:55 UTC 2023 , Edited by admin on Thu Jul 06 19:44:55 UTC 2023
PRIMARY
CAS
2226393-85-5
Created by admin on Thu Jul 06 19:44:55 UTC 2023 , Edited by admin on Thu Jul 06 19:44:55 UTC 2023
PRIMARY
FDA UNII
DW4CE8MKS9
Created by admin on Thu Jul 06 19:44:55 UTC 2023 , Edited by admin on Thu Jul 06 19:44:55 UTC 2023
PRIMARY
From To
1_22 1_95
1_151 1_207
1_268 1_328
1_374 1_432
2_22 2_95
2_151 2_207
2_268 2_328
2_374 2_432
1_227 3_214
1_233 2_233
1_236 2_236
2_227 4_214
3_23 3_89
3_134 3_194
4_23 4_89
4_134 4_194
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_304
N 2_304
Related Record Type Details
TARGET -> INHIBITOR
IPH5401 is a therapeutic human antibody that specifically binds and blocks C5a receptors (C5aR) expressed on subsets of myeloid-derived suppressor cells (MDSC) and neutrophils. IPH5401 blocks the binding of C5a to C5aR, thereby reducing the accumulation and activation of MDSC and neutrophils in tumors. Treatment with IPH5401 may unleash anti-tumor activities of T cells and NK cells.
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL