Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 14:09:20 UTC 2023
by
admin
on
Sat Dec 16 14:09:20 UTC 2023
|
| Protein Type | MONOCLONAL ANTIBODY |
| Protein Sub Type | IGG1 |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
DW4CE8MKS9
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
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Common Name | English | ||
|
Code | English | ||
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Common Name | English | ||
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Common Name | English | ||
|
Code | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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C163020
Created by
admin on Sat Dec 16 14:09:20 UTC 2023 , Edited by admin on Sat Dec 16 14:09:20 UTC 2023
|
PRIMARY | |||
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11081
Created by
admin on Sat Dec 16 14:09:20 UTC 2023 , Edited by admin on Sat Dec 16 14:09:20 UTC 2023
|
PRIMARY | |||
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2226393-85-5
Created by
admin on Sat Dec 16 14:09:20 UTC 2023 , Edited by admin on Sat Dec 16 14:09:20 UTC 2023
|
PRIMARY | |||
|
DW4CE8MKS9
Created by
admin on Sat Dec 16 14:09:20 UTC 2023 , Edited by admin on Sat Dec 16 14:09:20 UTC 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_22 | 1_95 |
| 1_151 | 1_207 |
| 1_268 | 1_328 |
| 1_374 | 1_432 |
| 2_22 | 2_95 |
| 2_151 | 2_207 |
| 2_268 | 2_328 |
| 2_374 | 2_432 |
| 1_227 | 3_214 |
| 1_233 | 2_233 |
| 1_236 | 2_236 |
| 2_227 | 4_214 |
| 3_23 | 3_89 |
| 3_134 | 3_194 |
| 4_23 | 4_89 |
| 4_134 | 4_194 |
| Glycosylation Type | MAMMALIAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_304 |
| N | 2_304 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
IPH5401 is a therapeutic human antibody that specifically binds and blocks C5a receptors (C5aR) expressed on subsets of myeloid-derived suppressor cells (MDSC) and neutrophils. IPH5401 blocks the binding of C5a to C5aR, thereby reducing the accumulation and activation of MDSC and neutrophils in tumors. Treatment with IPH5401 may unleash anti-tumor activities of T cells and NK cells.
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| Molecular Formula | CHEMICAL |
|
||||
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|