Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H32N6 |
| Molecular Weight | 380.5297 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCN(CCC)C1=CC(C)=NC2=C(C(C)=NN12)C3=C(C)C=C(N=C3)N(C)C
InChI
InChIKey=ANNRUWYFVIGKHA-UHFFFAOYSA-N
InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
| Molecular Formula | C22H32N6 |
| Molecular Weight | 380.5297 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. | 2013-03-01 |
|
| Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. | 2011-06-23 |
|
| Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus. | 2011-04 |
|
| Analysis of the hormone-binding domain of steroid receptors using chimeras generated by homologous recombination. | 2005-08-15 |
|
| Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. | 2004-09-19 |
|
| Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors. | 2003-06 |
|
| The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. | 2003-02 |
|
| Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. | 2000-06-27 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:22:32 GMT 2025
by
admin
on
Mon Mar 31 21:22:32 GMT 2025
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| Record UNII |
G82N555U1N
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| Record Status |
Validated (UNII)
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| Record Version |
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9821250
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DTXSID00173162
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195055-03-9
Created by
admin on Mon Mar 31 21:22:32 GMT 2025 , Edited by admin on Mon Mar 31 21:22:32 GMT 2025
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G82N555U1N
Created by
admin on Mon Mar 31 21:22:32 GMT 2025 , Edited by admin on Mon Mar 31 21:22:32 GMT 2025
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| Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
Ki
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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