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Details

Stereochemistry ACHIRAL
Molecular Formula C22H32N6
Molecular Weight 380.5297
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NBI-30775

SMILES

CCCN(CCC)C1=CC(C)=NC2=C(C(C)=NN12)C3=C(C)C=C(N=C3)N(C)C

InChI

InChIKey=ANNRUWYFVIGKHA-UHFFFAOYSA-N
InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3

HIDE SMILES / InChI

Molecular Formula C22H32N6
Molecular Weight 380.5297
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
50.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Analysis of the hormone-binding domain of steroid receptors using chimeras generated by homologous recombination.
2005 Aug 15
Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus.
2011 Apr
Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
2011 Jun 23
Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism.
2013 Mar 1
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 04:36:08 GMT 2023
Edited
by admin
on Sat Dec 16 04:36:08 GMT 2023
Record UNII
G82N555U1N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NBI-30775
Common Name English
R-121919
Code English
R121919
Code English
PYRAZOLO(1,5-A)PYRIMIDIN-7-AMINE, 3-(6-(DIMETHYLAMINO)-4-METHYL-3-PYRIDINYL)-2,5-DIMETHYL-N,N-DIPROPYL-
Systematic Name English
Code System Code Type Description
PUBCHEM
9821250
Created by admin on Sat Dec 16 04:36:08 GMT 2023 , Edited by admin on Sat Dec 16 04:36:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID00173162
Created by admin on Sat Dec 16 04:36:08 GMT 2023 , Edited by admin on Sat Dec 16 04:36:08 GMT 2023
PRIMARY
CAS
195055-03-9
Created by admin on Sat Dec 16 04:36:08 GMT 2023 , Edited by admin on Sat Dec 16 04:36:08 GMT 2023
PRIMARY
FDA UNII
G82N555U1N
Created by admin on Sat Dec 16 04:36:08 GMT 2023 , Edited by admin on Sat Dec 16 04:36:08 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY